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FLASH GENE
Symbol CKS1B contributors: mct/ - updated : 13-05-2009
HGNC name CDC28 protein kinase regulatory subunit 1B
HGNC id 19083
Location 1q21.3      Physical location : 154.947.117 - 154.951.724
Synonym name
  • PNAS-143
  • CDC28 protein kinase 1related protein
  • cyclin-dependent kinases regulatory subunit 1
  • CDC2-associated protein CKS1
  • cell division control protein CKS1
  • NB4 apoptosis/differentiation
  • Synonym symbol(s) CKS1, CKSHS1, PNAS-143, PNAS-16, PNAS-18
    DNA
    TYPE functioning gene
    STRUCTURE 4.61 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KCNN3 1q21.3 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 PMVK 1p13-q23 phosphomevalonate kinase PBXIP1 1q22 pre-B-cell leukemia transcription factor interacting protein 1 PYGO2 1q22 pygopus 2 SHC1 1q21 SHC (Src homology 2 domain containing) transforming protein 1 CKS1B 1q21.2 CDC28 protein kinase regulatory subunit 1B PP591 1q22 FAD-synthetase LENEP 1q22 lens epithelial protein ZFP67 1q21.2 zinc finger protein 67 homolog (mouse) FLJ32934 1q22 hypothetical protein FLJ32934 FLJ32785 1q22 hypothetical protein FLJ32785 ADAM15 1q21.3 a disintegrin and metalloproteinase domain 15 (metargidin) EFNA4 1q21-q22 ephrin-A4 EFNA3 1q21-q22 ephrin-A3 EFNA1 1q21-q22 ephrin-A1 LOC55974 1q22 stromal cell protein DPM3 1q21.2 dolichyl-phosphate mannosyltransferase polypeptide 3 KCP2 TRIM46 1q21-22 tripartite motif-containing 46 MUC1 1q21 mucin 1, transmembrane THBS3 1q21-q23 thrombospondin 3 MTX1 1q21 metaxin 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 834 9.53 79 - 2009 19161979
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas    
    Lymphoid/Immunethymus    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cell lineage
    cell lines non-small cell lung cancers
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, G1, S, G2
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • anion binding sites
  • mono polymer homomer , hexamer
    HOMOLOGY
    interspecies ortholog to murine Cks1
    homolog to yeast S.cerevisiae CKS1
    Homologene
    FAMILY
  • cyclin-dependent kinase subunit (CKS) family
  • CATEGORY adaptor , enzyme , regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • being essential for the biological function of the cyclin dependent kinases
  • involved in ubiquitin-dependant p27 proteolysis
  • required for the ubiquitination of CDKN1B
  • plays an important role for breast cancer development
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell cycle, checkpoint
    cell cycle, progression
    cell life, proliferation/growth
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • components of cyclin/cyclin-dependent kinase (cdk) complexes contributing to cell cycle control in all eukaryotes
  • INTERACTION
    DNA
    RNA
    small molecule other,
  • phosphate
  • protein
  • binding to the catalytic subunit of the cyclin dependent kinases, CDK2, SCFSkp2, p27
  • interacting with SKP2 (binds to and activates cyclin-dependent kinases and also interacts with SKP2 to promote the ubiquitination and proteasomal degradation of CDKN1B)
  • cell & other
    REGULATION
    inhibited by by the tumor suppressor TP53 which corresponds well with the idea that TP53 employs multiple ways in order to halt the cell cycle
    repressed by vitamin D analogs
    TGF-beta
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in mantle cell lymphoma blastoid variant, non-small cell lung cancers and adenocarcinoma
    tumoral   amplification --over  
    associated with reduced levels of CDKN1B and an aggressive clinical course in multiple myeloma
    tumoral   amplification --over  
    in breast cancer
    tumoral     --over  
    of CKS1B or SKP2 contributes to increased p27(Kip1) turnover, cell proliferation, and a poor prognosis in many tumor types
    tumoral   amplification    
    in cutaneous squamous cell carcinoma with aggressive clinical behaviour
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    therapeutic strategies aimed at abolishing CKS1B function may hold promise for the treatment of high-risk myeloma for which effective therapies are currently lacking
    cancerskin 
    Several drugs targeting CKS1B have been reported and may be useful for treating patients with cutaneous squamous cell carcinoma and CKS1B amplifications
    ANIMAL & CELL MODELS