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FLASH GENE
Symbol CKLF contributors: mct/npt - updated : 06-02-2012
HGNC name chemokine-like factor
HGNC id 13253
Location 16q22.1      Physical location : 66.586.465 - 66.600.154
Synonym name
  • transmembrane proteolipid
  • chemokine-like factor 3, alternatively spliced
  • Synonym symbol(s) C32, CKLF3, CKLF4, HSPC224, CKLF1, UCK-1, CKLF2, UNQ410/PRO772
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text with CMTM1 to 4 form a gene cluster
    STRUCTURE 13.72 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 splicing 729 10.9 99 - 2004 14672709
  • CKLF1
  • 4 splicing 688 17.2 152 transmembrane 2004 14672709
  • CKLF2
  • proteolipids, playing a role in regulation of skeletal muscle myogenesis
  • 2 splicing 633 7.7 67 - 2004 14672709
  • CKLF3
  • 3 splicing 792 13.9 120 - 2004 14672709
  • CKLF4
  • 4 - 691 - 113 - 2004 14672709
    2 - 794 - 168 - 2004 14672709
    2 - 715 - 92 - 2004 14672709
    1 - 635 - 115 - 2004 14672709
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrineadrenal gland   highly
     parathyroid   highly
    Hearing/Equilibriumear   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly Homo sapiens
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • the C-terminal two peptides C19 and C27 inhibit CXCL12-induced CXCR4-mediated chemotaxis and induce CXCR4 internalization
  • HOMOLOGY
    interspecies homolog to C.elegans F13H6.1
    Homologene
    FAMILY
  • CKLF-like MARVEL transmembrane domain containing family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • chemoattractant for neutrophils, monocytes and lymphocytes
  • playing a role in inflammation and in the regeneration of skeletal muscle
  • playing important roles in the immune system and participate in tumorigenesis
  • may be involved in T lymphocyte activation
  • exhibits chemotactic effects on leukocytes
  • secreted peptides of CKLF, C27 and C19, have functional activation via CCR4
  • induces nerve cell migration through the non-extracellular Ca2+-dependent tyrosine kinases pathway
  • CKLF1-C19 and -C27 can stimulate antigen-presenting capability of immature dendritic cells
  • cytokine, displaying chemotactic activities in a wide spectrum of leukocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with its C-terminal peptides can interact with CCR4
  • cell & other
    REGULATION
    inhibited by interleukin 10 in PHA-stimulated U937 cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    in asthma and rheumatoid arthritis (RA), disease conditions in which T lymphocytes are over-activated
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • useful marker for regenerating muscle fibers in inflammatory myopathies
  • Therapy target
    SystemTypeDisorderPubmed
    neurologyacquired 
    may be a potential therapeutic target for cerebral ischemia
    ANIMAL & CELL MODELS