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FLASH GENE
Symbol CKAP4 contributors: mct/npt/pgu - updated : 29-03-2010
HGNC name cytoskeleton-associated protein 4
HGNC id 16991
Location 12q23.3      Physical location : 106.631.659 - 106.641.713
Synonym name
  • transmembrane protein (63kD), endoplasmic reticulum/Golgi intermediate compartment
  • microtubule-binding 63-kDa cytoskeleton-linking membrane protein
  • Synonym symbol(s) P63, CLIMP-63, ERGIC-63, MGC99554
    DNA
    TYPE functioning gene
    STRUCTURE 10.05 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 3036 63 602 - 2001 11402071
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Reproductivefemale systemovary  highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmoothvessel  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal cytoplasmic domain
  • a single transmembrane domain
  • a rodlike tail sequence highly repetitive,with an heptad repeats forming an helical coiled coil structure involved in subcellular localization
  • conjugated PhosphoP
    mono polymer homomer , oligo
    HOMOLOGY
    Homologene
    FAMILY
  • VDP/USO1/YBl047C family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    text
  • type II transmembrane protein
  • CKAP4 palmitoylation by DHHC2 is required for its trafficking from the ER to the plasma membrane and for its nuclear localization)
  • exclusively localized in sheet-like ER membranes, typical structures of the rough ER, and plays a pivotal role in the static interaction with MTs
  • basic FUNCTION
  • involved in linking the ER to microtubules, and required for protein transport from the ER to the golgi complex
  • may contribute to the functional regulation of the plasminogen activation system in the vessel wall
  • important epithelial cell receptor for APF, Antiproliferative factor (APF) is a sialoglycopeptide that is secreted by bladder cells from interstitial cystitis patients, a potent inhibitor of both normal bladder epithelial and bladder carcinoma cell proliferation
  • CKAP4-mediated stable anchoring of the ER to microtubules is required to maintain the spatial distribution of the ER during interphase and this interaction is abolished by phosphorylation of CKAP4 during mitosis
  • role of CKAP4 as an SFTPA1 receptor protein localized on the surface of lung type II cells
  • role for TP73 and CKAP4 in supporting cellular proliferation through the transcriptional activation of the genes involved in G(1)-S and G(2)-M progression
  • reversibly palmitoylated and phosphorylated protein that links the ER to the cytoskeleton
  • CELLULAR PROCESS cell organization/biogenesis
    cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • major substrate of the palmitoyl acyltransferase, DHHC2
  • VIMP can interact with CKAP4 and SNX5, it does not interact with MT-binding ER proteins (such as REEP1) that shape the tubular smooth ER
  • cell & other
  • microtubules
  • REGULATION
    activated by olomoucine, a CDK inhibitor (strongly up-regulates CKAP4 in a dose- and time-dependent manner solely in senescent cells)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS