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FLASH GENE

Symbol

CKAP2L

contributors: mct - updated : 05-12-2014

HGNC name	cytoskeleton associated protein 2-like
HGNC id	26877

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CDSMR craniodigital syndrome with mental retardation
Location	2q13      Physical location : 113.495.443 - 113.522.254
Synonym name	radial fiber and mitotic spindle
Synonym symbol(s)	FLJ40629, MGC39683, Radmis

DNA

TYPE	functioning gene
STRUCTURE	26.81 kb     9 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_152515 9 - 3273 NP_689728 83.5 745 - 2014 25439729

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       predominantly   thymus       highly Nervous brain       highly Homo sapiens Fetal Reproductive male system testis     moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     moderately Connective bone     moderately

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to murine Radmis
	homolog to rattus Ckap2l (63.4 pc)
	homolog to murine Ckap2l (64.6 pc)

Homologene

FAMILY

CKAP2 family

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
text	. in embryonic and perinatal brains, localized to bipolar mitotic spindles and radial fibers (basal processes) of dividing neural stem/progenitor cells (NSPCs)
	in adult brain, radmis expression persisted in the mitotic spindles of both slowly-dividing stem cells and rapid amplifying progenitors

basic FUNCTION	microtubule-associated protein (MAP) enriched in neural stem/progenitor cells (NSPCs)
	indispensable role in mitotic spindle formation and cell-cycle progression of NSPCs
	play a pivotal role in cell division of neural progenitors

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

putative substrate for the E3-ubiquitin ligase, anaphase promoting complex/cyclosome (APC/C), and is degraded via the KEN box

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CDSMR

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS