Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | CISH | contributors: mct - updated : 28-05-2020 |
HGNC name | cytokine inducible SH2-containing protein |
HGNC id | 1984 |
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Location | 3p21.2 Physical location : 50.643.885 - 50.649.262 |
Synonym name | |
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Synonym symbol(s) | CIS, CIS-1, G18, SOCS, BACTS2 |
DNA |
TYPE | functioning gene |
STRUCTURE | 5.38 kb 3 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
physiological period | fetal, pregnancy |
Text | predominantly in kidney |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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HOMOLOGY |
interspecies | homolog to murine Cish |
Homologene |
FAMILY | suppressor of cytokine signaling (SOCS) family |
CATEGORY | signaling cytokine |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,nucleus | |
text | localization regulated by cellular conditions (nuclear localization being stimulated by conditions that increased cytoplasmic protein levels) |
basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling | signal transduction |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein | |
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cell & other |
REGULATION |
induced by | induced by IL2, IL3, EPO | |
TCR stimulation in CD8(+) T cells |
Other | CISH protein stability is regulated through multiple mechanisms, including ubiquitination and interaction with ELOB/ELOC proteins, whereas CISH functional inhibition of PRLR signaling is dependent on the ELOB/ELOC interaction |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |