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FLASH GENE
Symbol CIRBP contributors: mct - updated : 28-01-2015
HGNC name cold inducible RNA binding protein
HGNC id 1982
Location 19p13.3      Physical location : 1.269.266 - 1.274.809
Synonym name
  • glycine-rich RNA binding protein
  • Synonym symbol(s) CIRP
    DNA
    TYPE functioning gene
    STRUCTURE 5.54 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status confirmed
    Physical map
    PALM 19p13.3 paralemmin LOC126353 19p13.3 hypothetical protein LOC126353 PTBP1 19p13.3 polypyrimidine tract binding protein 1 FLJ11535 19p13.3 hypothetical protein FLJ11535 AZU1 19p13.3 azurocidin 1 (cationic antimicrobial protein 37) PRTN3 19p13.3 proteinase 3 (serine proteinase, neutrophil, Wegener granulomatosis autoantigen) ELA2 19p13.3 elastase 2, neutrophil DF 19p13.3 D component of complement (adipsin) TRAP95 MGC16353 19p13.3 hypothetical protein MGC16353 GPR54 19p13.3 G protein-coupled receptor 54 DRIL1 19p13.3 dead ringer-like 1 (Drosophila) WDR18 19p13.3 WD repeat domain 18 GRIN3B 19p13.3 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B C19orf6 19p13.3 chromosome 19 open reading frame 6 CNN2 21q11 calponin 2 ABCA7 19p13.3 ATP-binding cassette, sub-family A (ABC1), member 7 HA-1 19p13.3 ATP-binding cassette, sub-family A (ABC1), member 7 POLR2E 19p13.3 polymerase (RNA) II (DNA directed) polypeptide E, 25kDa GPX4 19p13.3 glutathione peroxidase 4 (phospholipid hydroperoxidase) KIAA0963 19p13.3 Homo sapiens KIAA0963 protein (KIAA0963), mRNA. STK11 19p13.3 serine/threonine kinase 11 (Peutz-Jeghers syndrome) MGC40084 19p13.3 hypothetical protein MGC40084 ATP5D 19p13.3 ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit MIDN 19pter-p13.3 midnolin MGC39338 19p13.3 hypothetical protein MGC39338 CIRBP 19p13.3-p13.2 cold inducible RNA binding protein FLJ20640 19p13.3 hypothetical protein FLJ20640 EFNA2 19p13.3 ephrin-A2 LOC388488 19 similar to Dip1-associated protein C MUM-1 NDUFS7 19p13 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) GAMT 19p13.3 guanidinoacetate N-methyltransferase DAZAP1 19p13.3 DAZ associated protein 1 RPS15 19p13.3 ribosomal protein S15 APCL 19p13.3 ribosomal protein S15 FLJ36666 19p13.3 hypothetical protein FLJ36666 PCSK4 19p proprotein convertase subtilisin/kexin type 4 DP1L1 19p13.3 polyposis locus protein 1-like 1 LOC339366 19p13.3 hypothetical protein LOC339366 LOC126520 19p13.3 hypothetical protein LOC126520 MBD3 19p13.3 methyl-CpG binding domain protein 3 UQCR 19p13.3 ubiquinol-cytochrome c reductase (6.4kD) subunit TCF3 19p13.3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) LOC126435 19p13.3 hypothetical LOC126435 LOC390874 19 similar to onecut 3 ATP8B3 19p13.3 ATPase, Class I, type 8B, member 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1397 18 172 - -
    - - 1170 - 168 - -
    - - 1790 - 297 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
     thymus   highly
    Nervousbrain   highly
     nerve   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal RNA Recognition Motif (RRM)
  • C-terminal domain containing several RGG motifs
  • HOMOLOGY
    interspecies homolog to murine Cirp
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus,nucleoplasm
    text
  • methylation of arginine residues in the RGG domain is necessary for CIRBP to exit the nucleus to be further recruited into stress granules (SGs)
  • basic FUNCTION
  • but likely excluded as the responsible gene
  • may be playing an essential role in cold-induced suppression of cell proliferation
  • may participate in the cell cycle regulation of normal endometrium and the loss of its expression may be involved in endometrial carcinogenesis
  • expression of CIRBP accelerates the G0/G1-to-S phase transition without affecting apoptosis
  • RBM3 and CIRBP are two established cold-shock proteins
  • CIRBP fine-tunes the cell-cycle progression of undifferentiated spermatogonia as well as fibroblasts and cancer cells by interacting with and suppressing kinase activity of DYRK1B to modulate the protein levels of CDKN1B and CCND1
  • RNA-binding protein that is expressed in normal testis and down-regulated after heat stress
  • CIRBP and RBM3, are important regulators for the temperature entrained circadian gene expression
  • extracellular CIRBP is a detrimental factor in stimulating inflammation to cause neuronal damage in cerebral ischemia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • CIRBP forms a complex together with DYRK1B and CCND1
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • mild hypothermia protects cells from TNF-induced apoptosis, at least partly, via induction of CIRBP, and CIRBP protects cells by activating the ERK pathway
  • CIRBP functions to fine-tune the proliferation of undifferentiated spermatogonia by interacting with DYRK1B
  • NFKB1-dependent role for CIRBP in regulating IL1B
  • CIRBP and RBM3 regulated the circadian gene expression by controlling alternative polyadenylation (APA)
  • cell & other
    REGULATION
    induced by stresses such as UV irradiation and hypoxia
    inhibited by the respiratory chain inhibitors NaN(3) and cyanide in a dose-dependent fashion
    repressed by TNF and TGFB1 that impair the expression of CIRBP in fibroblasts and neuronal cells
    Other cold inducible
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    may reduce the damage caused by testicular torsion/detorsion, possibly by preventing germ cell oxidative stress and apoptosis
    constitutional     --over  
    may reduce testicular damage induced by cryptorchidism by down-regulating the levels of TP53 and FAS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Cirp-deficient mice have reduced numbers of undifferentiated spermatogonia, although the total numbers of testicular germ cells and fertility were not significantly decreased