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FLASH GENE
Symbol CIR1 contributors: mct - updated : 02-07-2014
HGNC name corepressor interacting with RBPJ, 1
HGNC id 24217
Location 2q31.1      Physical location : 175.212.879 - 175.260.443
Synonym name
  • recepin
  • CBF1 interacting corepressor
    • Synonym symbol(s) CIR, CICR
    DNA
    TYPE functioning gene
    STRUCTURE 47.56 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1809 - 450 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a basic lysine and acidic serine-rich (BA) domain
  • a zinc knuckle-like motif
  • arginine/serine dipeptide repeat (RS) domain in its C terminal region
    • HOMOLOGY
    Homologene
    FAMILY family of SR-related proteins
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • colocalized with SRSF2 and RP9 in nuclear speckles
    • basic FUNCTION
  • act as a transcriptional corepressor
  • plays a role in splicing regulation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RP9 binding protein
  • interact with U2AF1 through the BA domain, with SRSF2 and SF2/ASF through the RS domain, and with RP9 outside the BA domain
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS