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FLASH GENE
Symbol CINP contributors: SGE/npt - updated : 06-05-2010
HGNC name cyclin-dependent kinase 2 interacting protein
HGNC id 23789
Location 14q32.31      Physical location : 102.814.620 - 102.829.253
Synonym symbol(s) MGC849
DNA
TYPE functioning gene
STRUCTURE 14.64 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1065 - 227 - -
- - 866 - 118 - -
5 - 996 - 212 - Grishina (2005)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • several phosphorylation sites
  • a CDK2 site near the N-terminus
  • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to rattus Cinp (78.3pc)
    Homologene
    FAMILY
  • CINP family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text
  • dissociates from chromatin with the strat of DNA replication
  • basic FUNCTION
  • part of a CDC7-dependent replication initiation complex and may function as a link between CDK2 and CDC7 complexes (Grishina 2005)
  • promotes cell viability in response to replication stress and is required for efficient ATR-dependent signaling after DNA damage (Lovejoy 2009)
  • CELLULAR PROCESS cell cycle, checkpoint
    nucleotide, replication
    nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of cyclin E/CDK2 and cyclin A/CDK2 complexes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CDK2, MCM5, CDC7, ATRIP
  • associated with ORC2
  • cell & other
    REGULATION
    Other phosphorylated by CDC7
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS