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FLASH GENE
Symbol CINP contributors: SGE/npt - updated : 06-05-2010
HGNC name cyclin-dependent kinase 2 interacting protein
HGNC id 23789
Location 14q32.31      Physical location : 102.814.620 - 102.829.253
Synonym symbol(s) MGC849
DNA
TYPE functioning gene
STRUCTURE 14.64 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC388017 14 LOC388017 LOC145197 14q32.32 hypothetical LOC145197 DIO3OS 14q32.33 deiodinase, iodothyronine, type III opposite strand DIO3 14q32 deiodinase, iodothyronine, type III LOC122423 14q32.33 similar to hypothetical protein ZC477.8 - Caenorhabditis elegans LOC388018 14 LOC388018 RPL26P4 14q32.34 ribosomal protein L26 pseudogene 3 C14orf72 14q32.33 chromosome 14 open reading frame 72 PPP2R5C 14q32.2 protein phosphatase 2, regulatory subunit B (B56), gamma isoform NPM1P20 14q32.33 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 20 DNCH1 14q32-qter dynein, cytoplasmic, heavy polypeptide 1 HSPCA 14q32.33 heat shock 90kDa protein 1, alpha WDR20 14q32.33 WD repeat domain 20 RAGE 14q32 renal tumor antigen C14orf131 14q32.33 chromosome 14 open reading frame 131 CINP 14q32.33 cyclin-dependent kinase 2-interacting protein KIAA0329 14q32-.11 cyclin-dependent kinase 2-interacting protein ANKRD9 14q32.33 ankyrin repeat domain 9 LOC283604 14q32.33 hypothetical LOC283604 RCOR 14q32.32 REST corepressor RPL23AP11 14 ribosomal protein L23a pseudogene 11 TRAF3 14q32.3 TNF receptor-associated factor 3 AMN 14q32.3 amnionless homolog (mouse) CDC42BPB 14q32.3 CDC42 binding protein kinase beta (DMPK-like) C14orf73 14 chromosome 14 open reading frame 73 TNFAIP2 14q32 tumor necrosis factor, alpha-induced protein 2 RPL21P12 14q32.33 ribosomal protein L21 pseudogene 12 RPL21P13 14 ribosomal protein L21 pseudogene 13 RPL17P4 14 ribosomal protein L17 pseudogene 4 LOC388019 14 LOC388019 EIF5 14q32.33 eukaryotic translation initiation factor 5
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1065 - 227 - -
- - 866 - 118 - -
5 - 996 - 212 - Grishina (2005)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • several phosphorylation sites
  • a CDK2 site near the N-terminus
    • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to rattus Cinp (78.3pc)
    Homologene
    FAMILY
  • CINP family
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text
  • dissociates from chromatin with the strat of DNA replication
    • basic FUNCTION
  • part of a CDC7-dependent replication initiation complex and may function as a link between CDK2 and CDC7 complexes (Grishina 2005)
  • promotes cell viability in response to replication stress and is required for efficient ATR-dependent signaling after DNA damage (Lovejoy 2009)
    • CELLULAR PROCESS cell cycle, checkpoint
    nucleotide, replication
    nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of cyclin E/CDK2 and cyclin A/CDK2 complexes
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CDK2, MCM5, CDC7, ATRIP
  • associated with ORC2
    • cell & other
    REGULATION
    Other phosphorylated by CDC7
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS