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FLASH GENE

Symbol

CILP2

contributors: mct - updated : 14-11-2012

HGNC name	cartilage intermediate layer protein 2
HGNC id	24213

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.11      Physical location : 19.649.073 - 19.657.466
Synonym symbol(s)	MGC45771, CLIP-2

DNA

TYPE	functioning gene
STRUCTURE	8.39 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_153221 8 - 4199 NP_694953 125 1156 - 2011 21880736

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous           Mus musculus Skeleton axial skeleton vertebral column vertebrae intervertebral disc   Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective cartilage fibrocartilage     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol not specific chondrocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a TSP-1 domain suggesting that it may be able to anchor to other matrix constituents

HOMOLOGY

intraspecies

homolog to CILP

Homologene

FAMILY

CATEGORY

SUBCELLULAR LOCALIZATION	extracellular
text	localized in the deeper intermediate zone of the articular cartilage extracellular matrix at maturity

basic FUNCTION	CILP and CILP2 may be important in cartilage structure and disease
	CILP and CILP2 can have additional roles in noncartilaginous tissue ECM structure and function
	ECM protein that may be components of such permanent cartilages, rather than the transient growth plate cartilage
	may contribute to the structural organization and matrix architecture within these connective tissues

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

may be part of collagen VI containing suprastructures in human articular cartilage

INTERACTION

DNA

RNA

small molecule

protein

may be associated with collagen VI microfibrils and thus may mediate interactions between matrix components in the territorial and inter-territorial articular cartilage matrix

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	could be potential biomarkers of arthritis or of metalloprotease activity in articular cartilage
Therapy target

ANIMAL & CELL MODELS

Cilp2 gene expression is dysregulated during cartilage degeneration in a mouse model of osteoarthritis reduced severalfold compared with sham operated joints