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FLASH GENE
Symbol CIDEC contributors: mct/npt - updated : 29-08-2015
HGNC name cell death-inducing DFFA-like effector c
HGNC id 24229
Location 3p25.3      Physical location : 9.908.398 - 9.920.740
Synonym name
  • cell death activator CIDE-3
  • fat specific protein 27
    • Synonym symbol(s) Fsp27, CIDE-3, FLJ20871, CIDE3, FPLD5
    DNA
    TYPE functioning gene
    STRUCTURE 13.55 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1217 - 251 - 2003 12429024
    7 - 1244 - 248 - 2003 12429024
    6 - 1214 26.6 238 - 2003 12429024
    6 - 1298 26.6 238 - 2003 12429024
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     intestinelarge intestinecolon  
    Reproductivefemale systembreastmammary gland  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectiveadipose  predominantly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • CIDE domains, previously associated with regulating apoptosis
  • a core domain (AAs 120-220), that interacts with PNPLA2 to inhibit its lipolytic function and promote triglyceride storage
    • HOMOLOGY
    interspecies homolog to murine Fsp27
    Homologene
    FAMILY
  • cell death-inducing DNA fragmentation factor-alpha-like effector family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • located in lipid droplets (LDs) and the endoplasmic reticulum (ER) and is induced in fat deposition
    • basic FUNCTION
  • having a apoptosis-inducing activity and an important role in prevention of tumorigenesis
  • playing a role in lipid-droplet structure or function
  • playing important roles in maintaining triglyceride stores in lean and obese individuals
  • CIDEA and CIDEC are novel genes regulated by insulin in human adipocytes and may play key roles in the effects of insulin, such as anti-apoptosis and lipid droplet formation (
  • CIDEA and CIDEC are closely involved in the progression of hepatic steatosis, and TIMP1 inhibits CIDEA gene expression through SREBF1 regulation
  • its expression suppressed liver fibrogenesis
  • promotes lipid droplet growth by initiating lipid exchange and transfer
  • crucial role for CIDEC-PNPLA2 interactions in regulating lipolysis, triglyceride accumulation, and insulin signaling in human adipocytes
  • protects likely lipid droplets (LDs) by decreasing the specific surface area (SSA) of LDs and is involved in the regulation of hepatic lipid deposition
  • plays a pivotal role in controlling the formation of large lipid droplet and energy metabolism
  • lipid droplet-associated protein that promotes intracellular triglyceride (TAG) storage.
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • expression of CIDEC in adipocytes is directly and crucially regulated by PPARG, a master transcription factor for the differentiation of adipocytes
  • CD5L is endocytosed into adipocytes, associates with FAS and suppresses its enzymatic activity, which reduces endogenous generation of fatty acids, resulting in decreased PPARG activity leading to downregulation of CIDEC and Perilipin mRNA levels
  • interaction between CIDEC and NFAT5 and CIDEC not only modulates lipid droplet (LD) homeostasis but also modulates the response to osmotic stress via a physical interaction with NFAT5 at the LD surface
  • PLIN1, another adipocyte-specific lipid droplet-associated protein, is an CIDEC activator (interacts with the CIDE-N domain of CIDEC and markedly increases CIDEC-mediated lipid exchange, lipid transfer and lipid droplet growth)
  • regulates both basal and stimulated lipolysis by interacting with adipose triglyceride lipase PNPLA2
  • TBC1D4 is the GTPase activating protein (GAP) for RAB8A, which forms a ternary complex with CIDEC and RAB8A to positively regulate Lipid droplets fusion
  • PRKAA1 is a negative regulator of CIDEC stability through the proteasomal ubiquitin-dependent protein catabolic process
  • is a direct transcriptional target of the nuclear receptor PPARA in hepatocytes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    depletion of CIDEC, but not CIDEA, significantly increased glycerol release from adipocytes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS