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FLASH GENE
Symbol CIDEA contributors: mct - updated : 22-10-2011
HGNC name cell death-inducing DNA fragmentation factor alpha-like effector a
HGNC id 1976
Location 18p11.21      Physical location : 12.254.317 - 12.277.592
Synonym name cell death activator
Synonym symbol(s) CIDE-A
DNA
TYPE functioning gene
STRUCTURE 23.28 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
Binding site
text structure
  • two Sp1/Sp3 binding sites in the promoter
  • SREBF1 markedly enhanced the promoter activity of CIDEA, and TIMP1 inhibited the expression of CIDEA mRNA (
  • MAPPING cloned Y linked N status provisional
    Physical map
    APCDD1 18p11.21 adenomatosis polyposis coli down-regulated 1 NAPG 18p11.21 N-ethylmaleimide-sensitive factor attachment protein, gamma LOC390831 18 similar to Phosphomannomutase 2 (PMM 2) FLJ23403 18p11.21 hypothetical protein FLJ23403 LOC342843 18p11.21 similar to hypothetical protein LOC284221 18p11.21 hypothetical protein LOC284221 FLJ34907 18p11.21 hypothetical protein FLJ34907 LOC388463 18 similar to acyl-malonyl condensing enzyme LOC388464 18 hypothetical gene supported by D86974 GNAL 18p11.31 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type CHMP1.5 18p11.21 CHMP1.5 protein MPPE1 18p11.21-p11.1 CHMP1.5 protein IMPA2 18p11.22-p11.21 inositol(myo)-1(or 4)-monophosphatase 2 LOC284226 18p11.21 similar to Kinesin-like protein KIF1C LOC284227 18p11.21 similar to single stranded DNA binding protein 4 LOC162835 18p11.21 similar to G protein-coupled receptor 124 LOC342850 18p11.21 similar to KIAA1074 protein LOC390832 18 similar to Phosphomannomutase 2 (PMM 2) CIDEA 18p11.21 cell death-inducing DFFA-like effector a MGC4083 18p11.21 tubulin beta MGC4083 AFG3L2 18p11 AFG3 ATPase family gene 3-like 2 (yeast) HFL-EDDG1 18p11.21 erythroid differentiation and denucleation factor 1 Spir-1 18p11.21 Spir-1 protein C18orf9 18p11.21 chromosome 18 open reading frame 9 HCCA3 18p11.21 hepatocellular carcinoma susceptibility protein PTPN2 18p11.22-p11.21 protein tyrosine phosphatase, non-receptor type 2 SEC13L 18p11.21 sec13-like protein LOC390833 18 similar to ribosomal protein P0-like protein; 60S acidic ribosomal protein PO; ribosomal protein, large, P0-like LOC388465 18 LOC388465 FLJ31338 18p11.21 hypothetical protein FLJ31338 C18orf1 18p11.2 chromosome 18 open reading frame 1 MGC24180 18p11.21 hypothetical protein MGC24180 RNMT 18p11.22 RNA (guanine-7-) methyltransferase MC5R 18p11.2 melanocortin 5 receptor MC2R 18p11.21 melanocortin 2 receptor (adrenocorticotropic hormone) LOC284230 18p11.21 similar to large subunit ribosomal protein L36a LOC162655 LOC342853 18p11.21 similar to KIAA0685 protein LOC388466 18 hypothetical gene supported by NM_032250
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1099 24.5 219 - 2011 21315073
    5 - 1324 28.1 253 - 2011 21315073
  • differing in the 5'UTR and CDs compared to variant 1
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousgangliaautonomic gangliasympathetic  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadiposewhite predominantly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificadipocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain is required for CIDEA-mediated development of enlarged lipid droplets
  • one CIDE-N domain
  • C-terminal domain directs lipid droplet targeting, lipid droplet clustering, and triglyceride accumulation
  • HOMOLOGY
    interspecies homolog to murine Cidea
    Homologene
    FAMILY cell death-inducing DNA fragmentation factor-alpha-like effector family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • colocalizes around lipid droplets with perilipin, a regulator of lipolysis
  • localizes to both the cytoplasm and the nucleus in human white adipocytes
  • basic FUNCTION
  • activator of apoptosis
  • playing an important role in lipolysis regulation and metabolic complications of obesity, which is at least in part mediated by cross-talk between CIDEA and TNF-alpha
  • playing a role in adipose tissue energy expenditure
  • mitochondrial protein that negatively regulates the activity of the BAT uncoupling protein UCP1
  • Cide domain-containing proteins play an important role in sequestration of triglyceride within adipocytes, promoting whole-body insulin sensitivity
  • plays a central role in controlling metabolic flux in human adipose tissues through its regulation of fat storage in lipid droplets
  • playing a role in lipid-droplet structure or function
  • playing important roles in maintaining triglyceride stores in lean and obese individuals
  • involved in adipose tissue loss in cancer cachexia and this may, at least in part, be due to its ability to inactivate pyruvate dehydrogenase complex (
  • CIDEA and CIDEC are novel genes regulated by insulin in human adipocytes and may play key roles in the effects of insulin, such as anti-apoptosis and lipid droplet formation (
  • CIDEA and CIDEC are closely involved in the progression of hepatic steatosis, and TIMP1 inhibits CIDEA gene expression through SREBF1 regulation
  • may prevent lipolysis by binding and shielding lipid droplets from lipase association
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to liver X receptors (NR1H2, NR1H3) and regulates their activity (could therefore be of importance for the regulation of metabolic processes in human adipose tissue)
  • cell & other
    REGULATION
    inhibited by by the DNA fragmentation factor DFF45
    DFFB
    repressed by CpG methylation of the promoter, regulating the Sp1/Sp3 binding sites
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    decreased twofold in obese humans and normalized after weight reduction
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target potential target for the treatment of obesity via the modulation of metabolic rate, based on the findings that CIDEA inhibits the brown adipose tissue uncoupling process
    ANIMAL & CELL MODELS