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FLASH GENE
Symbol CIBAR2 contributors: mct/npt - updated : 05-02-2020
HGNC name CBY1 interacting BAR domain containing 2
HGNC id 24781
Location 16q24.1      Physical location : -
Synonym name
  • hypothetical protein LOC339145
  • family with sequence similarity 92, member B
  • Synonym symbol(s) FLJ44299, MGC138149, FAM92B
    DNA
    TYPE functioning gene
    STRUCTURE 14.15 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1862 - 304 - 2016 27528616
    9 - 1197 - 299 - 2016 27528616
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary   
    Respiratoryrespiratory tracttrachea   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • predicted lipid-binding BAR domains, as novel CBY1-interacting partners
  • HOMOLOGY
    Homologene
    FAMILY
  • FAM92 family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • in airway multiciliated cells, both CIBAR1, CIBAR2 colocalize with CBY1 at the base of cilia
  • basic FUNCTION
  • CIBAR1, and CIBAR2 interact with CBY1 to promote ciliogenesis via regulation of membrane-remodeling processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CEP164 is necessary for the proper recruitment of another distal appendage/transition fiber protein Chibby1 (CBY1) and its binding partners CIBAR1 and CIBAR2 to the ciliary base in multiciliated cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS