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FLASH GENE
Symbol CIAPIN1 contributors: mct/npt - updated : 21-11-2019
HGNC name cytokine induced apoptosis inhibitor 1
HGNC id 28050
Location 16q21      Physical location : 57.462.086 - 57.481.369
Synonym name
  • anamorsin
  • fe-S cluster assembly protein DRE2 homolog
  • predicted protein of HQ0915
  • Synonym symbol(s) 2810413N20Rik, Anamorsin, PRO0915, DRE2, CIAE2, AM
    DNA
    TYPE functioning gene
    STRUCTURE 19.36 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2106 - 312 - Hao (2006)
    9 - 2160 - 299 - -
    8 - 2083 - 266 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain     Homo sapiens
     brainlimbic systemhippocampus highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • anamorsin family
  • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    intracellular,nucleus,nucleolus
    text
  • localized in both the cytoplasm and the nucleus and was accumulated in the nucleolus (Hao 2006)
  • located in the cytoplasm and in the mitochondrial intermembrane space (Zhang 2008)
  • basic FUNCTION
  • anti-apoptotic molecule that may undergo a cytoplasm-nucleus-nucleolus translocation (Hao 2006)
  • may be involved in cell differentiation, and it might exert universal and possibly important physiological functions under the regulation of Ras (Hao 2006)
  • essential conserved Fe/S cluster protein implicated in extramitochondrial Fe/S cluster assembly, similar to other components of the so-called CIA (cytoplasmic Fe/S cluster assembly) pathway although partially localized to the mitochondrial intermembrane space (Zhang 2008)
  • suppressor of gastric cancer cell proliferation and might play an important role in the development of gastric cancer (Zhang 2008)
  • played an important role in the differentiation of Colorectal cancer (CRC) cells, and the differential expression of CIAPIN1 in CRC was closely related to prognosis
  • CIAPIN1 and GLRX3 might play cooperatively essential roles in embryogenesis as iron-sulfur cluster proteins
  • implicated in cytosolic iron-sulfur (Fe/S) protein biogenesis
  • is the first identified Fe/S protein imported into the mitochondrial intermembrane space (IMS), raising the possibility that it plays a role in cytosolic Fe/S cluster biogenesis also once trapped in the IMS
  • participate in the process of proliferation and tumorigenicity for several cancers
  • implicated in several processes, such as apoptosis, cell division, angiogenesis and Fe/S protein biogenesis
  • is an antiapoptotic molecule that confers factor-independent survival on hematopoietic cells
  • essential for both autonomous and extrinsic regulation of fetal liver hematopoiesis
  • is a potential tumor suppressor
  • involved in cell survival including dopaminergic neuronal cells
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CIAPIN1 and CHCHD4 interact through an intermolecular disulfide-bonded intermediate and CIAPIN1 is imported into mitochondria
  • CIAPIN1 played an important role in the proliferation of liver cancer cells through increasing the expressions of cell cycle related proteins CCND1, CDK2, CDK4, and CCNE
  • Tat-CIAPIN1 protein has protective effects against hippocampal neuronal cell damage induced by ischemic injury, suggesting that Tat-CIAPIN1 protein may provide a potential therapeutic agent for ischemia
  • cell & other
    REGULATION
    Other specifically cleaved by CASP3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in clear cell renal cell carcinoma (He 2009)
    tumoral     --low  
    in gastric cancer tissues as compared to the matched adjacent nonneoplastic tissues (Li 2007)
    tumoral     --low  
    could sensitize leukemia cells to chemotherapeutic drugs by downregulating ABCB1 and BCL2 and by upregulating BAX, yet not altering either glutathione-S-transferase activity or intracellular glutathione content in leukemia cells (Li 2007)
    tumoral     --low  
    downregulation of the CIAPIN1 gene in multiple myeloma (MM) cells may be associated with the development of this disease
    tumoral     --over  
    of nuclear CIAPIN1 negatively correlated with the survival of epithelial ovarian cancer (EOC) patients
    tumoral     --low  
    in pancreatic cancer cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • CIAPIN1 and ABCA13 may be novel markers of poor outcome in pre-chemotherapy ovarian serous carcinoma effusions
  • nuclear CIAPIN1 might serve as a prognostic biomarker for epithelial ovarian cancer (EOC) patients
  • might possibly be used as an independent prognostic factor for pancreatic cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivepancreas
    potential therapeutic target for pancreatic cancer
    ANIMAL & CELL MODELS
  • Ciapin1-deficient mouse embryos are anemic
  • Ciapin1-deficient mice die during late gestation, and Ciapin1-deficient embryos are anemic and very small compared to wild type (WT) embryos