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FLASH GENE
Symbol CIAO2A contributors: mct - updated : 18-12-2019
HGNC name family with sequence similarity 96, member A
HGNC id 26235
Location 15q22.31      Physical location : -
Synonym symbol(s) FLJ22875, CIA2A, FAM96A, DUF59
DNA
TYPE functioning gene
STRUCTURE 21.45 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1108 18 160 - 2015 25716227
4 - 1058 11 102 - 2015 25716227
3 - 3527 - 102 - 2015 25716227
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland    
Endocrinepancreas    
 parathyroid    
Lymphoid/Immunelymph node    
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunemacrophage Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
  • FAM96 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text
  • is cytoplasmic
  • basic FUNCTION
  • share intriguing characteristics with amyloidogenic proteins
  • specifically matures iron regulatory protein 1 (ACO1), which is critical for cellular iron homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • is likely a novel pro-apoptotic tumor suppressor that is lost during gastrointestinal stromal tumors (GISTs) tumorigenesis
  • in the CIA pathway, CIAO1 cooperates with CIAO2A, CIAO2B, and MMS19 targeting factors to form various complexes that mediate the dedicated maturation of specific Fe/S recipient proteins
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CIAO2A bind APAF1 and enhances the induction of mitochondrial apoptosis
  • CIAO2A and CIAO2B form mutually exclusive complexes with CIAO1 to allow for selective interaction with different target Fe/S protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS