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FLASH GENE
Symbol CIAO1 contributors: SGE/npt - updated : 11-03-2010
HGNC name cytosolic iron-sulfur protein assembly 1 homolog (S. cerevisiae)
HGNC id 14280
Location 2q11.2      Physical location : 96.931.883 - 96.939.892
Synonym name
  • functional modulator of the transcriptional activation function Wilms tumor suppressor gene (WT1)
  • WD repeat domain 39
  • WD40 protein Ciao1
  • probable cytosolic iron-sulfur protein assembly protein CIAO1
  • Synonym symbol(s) CIA1, WDR39
    DNA
    TYPE functioning gene
    STRUCTURE 8.01 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC129870 2q11.2 similar to autoantigen NOR-90 LOC389004 2 similar to tripartite motif-containing 43 FLJ14082 2q11.2 hypothetical protein FLJ14082 LOC389005 2 similar to RING finger protein 18 (Testis-specific ring-finger protein) TRIM43 2q11 tripartite motif-containing 43 LOC285031 2q11.2 similar to autoantigen NOR-90 LOC129872 2q11.2 similar to Glycerol-3-phosphate acyltransferase, mitochondrial precursor (GPAT) LOC150759 2q11.2 hypothetical protein LOC150759 LOC389006 2 similar to KIAA1641 protein LOC389007 2 similar to hypothetical protein LOC150763 2q11.2 hypothetical protein LOC150763 ADRA2B 2p13-q13 adrenergic, alpha-2B-, receptor LOC200515 2q11.2 similar to hypothetical protein 7420700F21 DUSP2 2q11 dual specificity phosphatase 2 STARD7 2q11.1 START domain containing 7 FLJ20507 2q11.2 hypothetical protein FLJ20507 CIAO1 2q11.2 hypothetical protein FLJ20507 U5-200KD 2q11.1 hypothetical protein FLJ20507 KIAA1754L 2q11.2 KIAA1754-like BRRN1 2q11.2 barren homolog (Drosophila) LOC93082 2q11.2 hypothetical protein BC012317 MRF-1 FLJ10081 2p12-p11.2 hypothetical protein FLJ10081 LOC391408 2 similar to myoferlin isoform b; fer-1-like 3 LOC90342 2q11.2 similar to fer-1 like protein 3 LMAN2L 2q11.1 lectin, mannose-binding 2-like CNNM4 2p12-p11.2 cyclin M4 LOC130643 2q11.2 hypothetical LOC130643 CNNM3 2p12-p11.2 cyclin M3 DARP MGC41816 2q11.2 hypothetical protein MGC41816 SEMA4C 2q11.1 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C LOC51252 2q11.2 hypothetical protein LOC51252 LOC391409 2 hypothetical gene supported by NM_138800
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 4053 - 339 - Johnstone 1998
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven WD40 repeats
  • HOMOLOGY
    interspecies homolog to murine Ciao1 (95.0pc)
    homolog to rattus Ciao1 (94.4pc)
    Homologene
    FAMILY
  • WD repeat CIA1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • functional modulator of the transcriptional activation function Wilms tumor suppressor gene (WT1)
  • required for the maturation of extramitochondrial Fe/S proteins (Srinavasan 2007)
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • essential component of the cytosolic Fe/S protein assembly machinery
  • FAM96B-CIAO1-MMS19 complex binds to and facilitates assembly of most cytosolic-nuclear Fe/S proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with WT1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS