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FLASH GENE
Symbol CHTF8 contributors: mct/npt - updated : 09-04-2018
HGNC name CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
HGNC id 24353
Location 16q22.1      Physical location : 69.151.911 - 69.166.493
Synonym name
  • decreased expression in renal and prostate
  • chromosome transmission fidelity factor 8
  • CTF8, chromosome transmission fidelity factor 8 homolog
  • Protein DERPC
  • decreased expression in renal and prostate cancer protein
  • Synonym symbol(s) DERPC, FLJ20400, CTF8
    DNA
    TYPE functioning gene
    STRUCTURE 14.57 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2961 13.3 121 - 2010 20826785
    3 - 2903 - 102 - 2010 20826785
  • lacking an alternate in-frame exon in the 5' coding region and uses a downstream start codon
  • - - 596 - 99 - 2010 20826785
    uses an alternate splice site in the 3' coding region and lacks the 3'-terminal exon, has a distinct 3' UTR
    4 - 2929 - 121 - 2010 20826785
    differs in the 5' UTR
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver   highly
    Nervousbrainbasal nucleicaudate nucleus  
     brainbasal nucleicorpus callosum  
    Reproductivemale systemtestis  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to zebrafish Dr.24240
    homolog to xenopus Xl.105691
    Homologene
    FAMILY
  • CTF8 family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • may be implicated in tumorigenesis of kidney and prostate
  • involved in establishment of sister chromatid cohesion
  • CHTF8-RFC1 has additional important functions in preserving genome stability, besides its role in sister chromatid cohesion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • C-terminal 23-AA stretch of CHTF18 was necessary for the trimeric association of complex CHTF18, DSCC1, and CHTF8 and was required for the stable interaction
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CHTF18-DSCC1-CHTF8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA (Bermudez 2003)
  • CHTF18-RFC1 clamp loader contains a unique module in which the DSCC1-CHTF8 complex is bound to the C terminus of CHTF18 (the CHTF18-DSCC1-CHTF8 module)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    prostate and renal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS