basic FUNCTION
| having ATP binding activity |
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may be involved in cohesion establishment during S phase |
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binds chromatin during S phase suggesting a role during replication |
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involved in damage-induced homologous recombination |
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with WDHD1, and ATAD5 may coordinate the relative movement of the replication fork with respect to the cohesin ring (Parnas 2009) |
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CHTF18 confers likely protection against stalling and/or breaks at the replication fork in cells that either lack, or are compromised for, telomerase activity |
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CHTF18-RFC1 clamp loader contains a unique module in which the DSCC1-CHTF8 complex is bound to the C terminus of CHTF18 (the CHTF18-DSCC1-CHTF8 module) |