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FLASH GENE
Symbol CHSY3 contributors: mct/npt - updated : 22-04-2009
HGNC name chondroitin sulfate synthase 3
HGNC id 24293
Location 5q13-q23.3      Physical location : 129.240.522 - 129.522.326
Synonym name
  • chondroitin synthase 2
  • glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II
  • carbohydrate synthase 2
    • Synonym symbol(s) CHSY2, CHSY-2, CSS3
    EC.number 2.4.1.175/ 2.4.1.226
    DNA
    TYPE functioning gene
    STRUCTURE 281.80 kb     3 Exon(s)
    regulatory sequence Binding site
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3523 100.3 882 - Izumikawa (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a beta 3-glycosyltransferase motif
  • a beta 4-glycosyltransferase motif similar to that found in CSS1
    • HOMOLOGY
    intraspecies homolog to CHSY1
    Homologene
    FAMILY
  • chondroitin N- acetylgalactosaminyltransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II membrane protein
    basic FUNCTION
  • glycosyltransferase having both glucuronyltransferase and N-acetylgalactosaminyltransferase activities
  • possess GalNAcT-II (N-acetylgalactosaminyltransferase-II) and GlcAT-II (glucuronyltransferase-II) activities responsible for the elongation of CS (chondroitin sulfate) chains but cannot polymerize chondroitin chains by themselves (Izumikawa 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interactions between any two of CHSY1, CHSY3 and CHPF (Izumikawa 2007)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS