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FLASH GENE
Symbol CHST8 contributors: mct/npt - updated : 07/11/2008
HGNC name carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
HGNC id 15993
Location 19q13.1      Physical location : 34.112.860 - 34.264.413
Synonym name
  • N-acetylgalactosamine-4-O-sulfotransferase 1
  • GalNAc-4-O-sulfotransferase 1
  • carbohydrate sulfotransferase 8
  • Synonym symbol(s) GALNAC-4-ST1, GalNAc4ST-1, GalNAc4ST
    EC.number 2.8.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 88.98 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text Variants 1, 2, and 3 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2340 48 424 - Hiraoka (2001)
    - - 2251 48 424 - Hiraoka (2001)
    4 - 2496 48 424 - Hiraoka (2001)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    endocrinebraindiencephalonpituitary predominantly
    Endocrinepancreas    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one single transmembrane segment
  • four N minked glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Chst8
    homolog to Drosophila CG6523
    intraspecies homolog to C4S1
    homolog to C4S2
    Homologene
    FAMILY
  • sulfotransferase 2 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • type II membrane protein
  • one soluble form also sulfating chondroitin
  • basic FUNCTION
  • sulfate addition to the N-linked oligosaccharides of LH and other pituitary hormones
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    oligosaccharides
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other required for activity of LH and other pituitary hormones
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS