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FLASH GENE
Symbol CHST2 contributors: - updated : 05-05-2006
HGNC name carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
HGNC id 1970
Location 3q24      Physical location : 142.838.667 - 142.841.810
Synonym name carbohydrate (N acetyl/glucosamin-6-0) sulfotransferase 2
Synonym symbol(s) C6ST
EC.number 2.8.2.21, 2.8.2.5
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure one encoding exon
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Nervousbrain   highly
 spinal cord    
Reproductivefemale systemovary   
 male systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialbarrier/lining   
Lymphoid    
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
N terminal hydrophobic region,type II transmembrane protein
HOMOLOGY
interspecies homolog to murine Chst2
homolog to Drosophila CG1332
homolog to C.elegans T01H10.8
Homologene
FAMILY
CATEGORY enzyme , immunity/defense
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
text Golgi membrane-bound
basic FUNCTION
  • keratan sulfotransferase
  • chondroitin 6-sulfotransferase key enzyme 2
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development , inflammation
    text blood cells neurons
    PATHWAY
    metabolism carbohydrate
    signaling
    oligosaccharides
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS