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Symbol CHST12 contributors: npt/ - updated : 12-07-2006
HGNC name carbohydrate (chondroitin 4) sulfotransferase 12
HGNC id 17423
Location 7p22      Physical location : 2.443.258 - 2.474.214
Synonym name
  • chondroitin 4-o-sulfotransferase 2
  • sulfotransferase Hlo
    • Synonym symbol(s) C4ST2, C4S-2
    EC.number 2.8.2.5
    DNA
    TYPE functioning gene
    STRUCTURE 31.00 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2093 48.3 414 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain    
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C terminal catalytic domain
  • four potential sites for N glycosylation
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine c4st2-pending
    homolog to Drosophila CG4826
    Homologene
    FAMILY
  • sulfotransferase 2 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II transmembrane protein
    basic FUNCTION
  • for the synthesis of dermatan and chondroitin sulfate, transfering sulfate to the C-4 position of N-acetylgalactosamine
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS