Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CHST11 contributors: mct - updated : 28-08-2015
HGNC name carbohydrate (chondroitin 4) sulfotransferase 11
HGNC id 17422
Location 12q23.3      Physical location : 104.850.691 - 105.155.783
Synonym name
  • chondroitin 4-sulfotransferase
  • chondroitin 4-O-sulfotransferase 1
  • Synonym symbol(s) C4ST1, C4ST, HSA269537
    EC.number 2.8.2.5
    DNA
    TYPE functioning gene
    STRUCTURE 305.10 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ20641 12q23.3 hypothetical protein FLJ20641 PMCH 12q23.1 pro-melanin-concentrating hormone IGF1 12q23.1 insulin-like growth factor 1 (somatomedin C) PAH 12q23.1 phenylalanine hydroxylase ASCL1 12q23.1 achaete-scute complex-like 1 (Drosophila) FLJ25323 12q23.3 FLJ25323 protein STAB2 12q33.3 stabilin 2 TU12B1-TY 12q22-q23.1 TU12B1-TY protein LOC253724 12q23.3 hypothetical LOC253724 LOC283350 12q23.3 similar to cDNA sequence BC030307 TRA1 12q23.1 tumor rejection antigen (gp96) 1 LOC387881 12 LOC387881 TDG 12q22-24.1 thymine-DNA glycosylase LOC83468 12q gycosyltransferase HCF-2 12q23.3 host cell factor 2 NFYB 12q22-q23 nuclear transcription factor Y, beta LOC390354 12 similar to ribosomal protein L18a; 60S ribosomal protein L18a TXNRD1 12q23-q24 thioredoxin reductase 1 CHST11 12q23.2-q23.3 carbohydrate (chondroitin 4) sulfotransferase 11 DKFZP434K0427 12q24.11 hypothetical protein DKFZp434K0427 LOC121054 12q24.11 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) MGC40397 12q24.11 hypothetical protein MGC40397 FLJ38508 12q24.11 hypothetical protein FLJ38508 KIAA1033 12q24.11 KIAA1033 protein DIP13B 12q24.1 DIP13 beta LOC387882 12 hypothetical gene supported by AJ311377; BC013920 LOC390355 12 similar to dynein, axonemal, heavy chain 11; situs inversus viscerum; dynein, axon, heavy chain 11 LOC245718 12q24.11 similar to heat shock 70kD protein binding protein; progesterone receptor-associated p48 protein; putative tumor suppressor ST13; Hsp70-interacting protein ARK5 12q24.11 AMP-activated protein kinase family member 5 LOC341378 12q24.11 similar to thyroid hormone receptor interactor 11; thyroid receptor interacting protein 11 CKAP4 12q24.11 cytoskeleton-associated protein 4 MGC40368 12q24.11 hypothetical protein MGC40368 RPC2 12q24.11 RNA polymerase III subunit RPC2 RFX4 12q24 regulatory factor X, 4 (influences HLA class II expression)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 5768 41.4 352 - 2012 22317973
    3 - 5753 - 347 - 2012 22317973
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus   highly
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two functional intronic PPARG binding sites
  • four potential sites for N-glycosylation
  • a C terminal catalytic domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine C4st
    homolog to Drosophila CG4826
    intraspecies homolog to C4ST2
    Homologene
    FAMILY
  • sulfotransferase 2 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II transmembrane protein
    basic FUNCTION
  • the synthesis of dermatan and chondroitin sulfate, transfering sulfate to the C4 position of N-acetylgalactosamine
  • chondroitin 4-O-sulfation by CHST11 is required for proper chondroitin sulfate localization, modulation of distinct signaling pathways and cartilage growth plate morphogenesis
  • Golgi-bound enzyme involved in the biosynthesis of the glycosaminoglycan chondroitin sulfate
  • is a key downstream target of WNT signaling that regulates WNT diffusion from WNT-producing cells
  • can sulphate chondroitin, a major glycosaminoglycan involved in development and disease
  • may play a direct role in progression of breast cancer and its expression is controlled by DNA methylation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    proteoglycan
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a negatively regulated target gene of HRAS signaling
  • CHST11 is a novel PPARG target gene
  • TWIST1-binding sequences associated with CHST11, LITAF, ROR2, and SPATA5 also bound the potential TWIST1 cofactor RREB1
  • cell & other
    REGULATION
    Other regulation of CHST11 expression by opposing effects of arylsulfatase B on BMP4 and WNT9A
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal carcinomas
    tumoral     --over  
    highly expressed in breast cancer tissues compared to normal tissues and the expression levels were significantly associated with tumor progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • CHST11 is independent unfavorable prognostic factor in ovarian cancer
  • Therapy target
    ANIMAL & CELL MODELS
  • mouse C4st-1 as a target gene of ligands of the TGFbeta superfamily of growth factors, which could positively regulate C4st-1 expression in a number of cell types