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FLASH GENE

Symbol

CHST1

contributors: mct - updated : 20-09-2004

HGNC name	carbohydrate (keratan sulfate GAL-6) sulfotransferase 1
HGNC id	1969

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11p11.2-p11.1      Physical location : 45.670.426 - 45.687.172
Synonym name	carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
Synonym symbol(s)	C6ST , KSGAL6ST, KS6ST
EC.number	2.8.2.21

DNA

TYPE	functioning gene
STRUCTURE	16.00 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

text structure

intronless coding region

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 4 - 2733 - 411 - Kitayama (2007)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessels aorta     highly Digestive mouth           salivary gland         Endocrine neuroendocrine pituitary       Nervous brain       highly Visual eye anterior segment cornea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining       Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a RGD sequence

HOMOLOGY

interspecies	homolog to murine Chst1
	homolog to Drosophila CG1332
	homolog to C.elegans T01H10.8

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	Golgi membrane-bound
	type II transmembrane protein

basic FUNCTION	its activation facilitates Schwann cell migration during axonal growth
	maybe involved in the biosynthesis of keratan sulfate in the brain and in the cornea

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text	chondrogenesis

PATHWAY

metabolism

carbohydrate

signaling

polysaccharides biosynthesis of keratan sulfate in brain and cornea

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS