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FLASH GENE
Symbol CHRM4 contributors: mct - updated : 17-11-2011
HGNC name cholinergic receptor, muscarinic 4
HGNC id 1953
Location 11p11.2      Physical location : 46.406.639 - 46.408.107
Synonym symbol(s) M4R
DNA
TYPE functioning gene
STRUCTURE 1.47 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status provisional
Physical map
LOC219638 11p11.2 similar to KIAA0543 protein SYT13 11p12-p11 synaptotagmin XIII CHST1 11p11.2-p11.1 carbohydrate (keratan sulfate GAL-6) sulfotransferase 1 DKFZp779M0652 11p11.2 hypothetical protein DKFZp779M0652 SLC35C1 11p11.2 solute carrier family 35, member C1 CRY2 11p12-q21.1 cryptochrome 2 (photolyase-like) MAPK8IP1 11p12-p11.2 mitogen-activated protein kinase 8 interacting protein 1 LOC143678 11p11.2 similar to RIKEN cDNA 1700021K07 PEX16 11p11.11 peroxisomal biogenesis factor 16 GYLTL1B 11p11.2 glycosyltransferase-like 1B BHC80 11p11.2 glycosyltransferase-like 1B CREB3L1 11p11.2 cAMP responsive element binding protein 3-like 1 DGKZ 11p11.2 diacylglycerol kinase, zeta 104kDa MDK 11p11.2 midkine (neurite growth-promoting factor 2) CHRM4 11p12-p11.2 cholinergic receptor, muscarinic 4 LOC387765 11 LOC387765 FLJ20294 11p11.2 hypothetical protein FLJ20294 FLJ32675 11p11.2 hypothetical protein FLJ32675 KIAA0652 11p12-q11 hypothetical protein FLJ32675 ARHGAP1 11p12-q12 Rho GTPase activating protein 1 ZNF408 11p11.2 zinc finger protein 408 F2 11p11-q12 coagulation factor II (thrombin) ch-TOG 11p11.2 KIAA0097 gene product LRP4 11p12-p11.2 low density lipoprotein receptor-related protein 4 MGC4707 11p11.2 hypothetical protein MGC4707 ZNF289 11p11.2-p11.12 zinc finger protein 289, ID1 regulated PACSIN3 11p12-p11.2 protein kinase C and casein kinase substrate in neurons 3 DDB2 11p12-p11.2 damage-specific DNA binding protein 2, 48kDa ACP2 11p11.2 acid phosphatase 2, lysosomal NR1H3 11p11.2 nuclear receptor subfamily 1, group H, member 3 MADD 11p11.22-p11.21 MAP-kinase activating death domain MYBPC3 11p11.2 myosin binding protein C, cardiac SPI1 11p12 spleen focus forming virus (SFFV) proviral integration oncogene spi1 SLC39A13 11p11.2 solute carrier family 39 (zinc transporter), member 13
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1468
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen    
Nervousbrainforebrain  highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
conjugated GlycoP
HOMOLOGY
interspecies ortholog to rattus Chrm4
ortholog to murine Chrm4
Homologene
FAMILY G protein coupled receptor superfamily
CATEGORY receptor , transport channel
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • regulate the dynamics of cholinergic and dopaminergic neurotransmission
  • regulate the dynamics of cholinergic and dopaminergic neurotransmissionneuronal CHRM4 plays a critical role in modulating several important dopamine-dependent behaviors
  • CHRM1, and CHRM4, are the major muscarinic ACh receptors subtypes responsible for direct cholinergic modulation of the excitatory hippocampal circuit
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CAMK2A binds directly and selectively to one of five mAChR subtypes, CHRM4, at its C-terminal regions of second intracellular loops
  • cell & other
    REGULATION
    Other regulated by CAMK2A (in a Ca(2+)-sensitive manner, regulates CHRM4 efficacy and controls the acetylcholine-dopamine balance in the basal ganglia and also the dynamics of movement)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurology  
    M4 receptor agonists could represent an innovative strategy for the treatment of pathologies associated with hyperdopaminergia
    ANIMAL & CELL MODELS