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FLASH GENE

Symbol

CHRM4

contributors: mct - updated : 17-11-2011

HGNC name	cholinergic receptor, muscarinic 4
HGNC id	1953

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11p11.2      Physical location : 46.406.639 - 46.408.107
Synonym symbol(s)	M4R

DNA

TYPE	functioning gene
STRUCTURE	1.47 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000741 1 - 1468

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen         Nervous brain forebrain     highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to rattus Chrm4
	ortholog to murine Chrm4

Homologene

FAMILY

G protein coupled receptor superfamily

CATEGORY

receptor , transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	regulate the dynamics of cholinergic and dopaminergic neurotransmission
	regulate the dynamics of cholinergic and dopaminergic neurotransmissionneuronal CHRM4 plays a critical role in modulating several important dopamine-dependent behaviors
	CHRM1, and CHRM4, are the major muscarinic ACh receptors subtypes responsible for direct cholinergic modulation of the excitatory hippocampal circuit

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

CAMK2A binds directly and selectively to one of five mAChR subtypes, CHRM4, at its C-terminal regions of second intracellular loops

cell & other

REGULATION

Other

regulated by CAMK2A (in a Ca(2+)-sensitive manner, regulates CHRM4 efficacy and controls the acetylcholine-dopamine balance in the basal ganglia and also the dynamics of movement)

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology     M4 receptor agonists could represent an innovative strategy for the treatment of pathologies associated with hyperdopaminergia

ANIMAL & CELL MODELS