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FLASH GENE
Symbol CHRAC1 contributors: - updated : 29-08-2005
HGNC name chromatin accessibility complex 1
HGNC id 13544
Location 8q24.3      Physical location : 141.521.400 - 141.527.252
Synonym name histone-fold protein CHRAC15
Synonym symbol(s) YCL1, CHRAC15, CHARC1, CHARC15
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC51059 8q24.3 hypothetical protein LOC51059 COL22A1 8q24.3 collagen, type XXII, alpha 1 KCNK9 8q24.2 potassium channel, subfamily K, member 9 T1 8q24.3 Tularik gene 1 C8orf17 8q24.3 chromosome 8 open reading frame 17 CHRAC1 8q24.3 chromatin accessibility complex 1 EIF2C2 8q24 eukaryotic translation initiation factor 2C, 2 PTK2 8q24-qter PTK2 protein tyrosine kinase 2 KIAA0870 8q24.3 KIAA0870 protein KIAA1126 8q24.3 KIAA1126 protein LOC137485 8q24.3 hypothetical gene LOC137485 LOC389689 8 LOC389689 GPR20 8q24.2-q24.3 G protein-coupled receptor 20 PTP4A3 8q24.3 protein tyrosine phosphatase type IVA, member 3 LOC389690 8 similar to FLJ46354 protein LOC392273 8 similar to Dnajc8 protein FLJ31164 8q24.3 hypothetical protein FLJ31164 BAI1 8q24 brain-specific angiogenesis inhibitor 1 ARC 8q24.3 activity-regulated cytoskeleton-associated protein JRK 8q24.3 jerky homolog (mouse) PSCA 8q24.2 prostate stem cell antigen HSJ001348 8q24.3 cDNA for differentially expressed CO16 gene LOC51337 8q24.3 mesenchymal stem cell protein DSCD75 ARS LOC137797 8q24.3 similar to RGTR430 LYNX1 8q24.3 similar to RGTR430 E48 GML 8q24.3 GPI anchored molecule like protein CYP11B1 8q21 cytochrome P450, family 11, subfamily B, polypeptide 1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
histone fold domains
mono polymer heteromer , complex
HOMOLOGY
interspecies homolog to murine Chrac1
homolog to Drosophila iswi
Homologene
FAMILY
  • histone-fold superfamily
  • H2A-H2B subfamily
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • playing a role in heterochromatin dynamics
  • important for cell viability,developmental gene expression and chromosome structure
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the human ISWI chromatin remodelling complex with ACF1 and another histone-fold protein POLE3, component of the nucleolar chromatin remodeling complexes and of the chromatin remodeling and spacing factor RSF(ACF and CHRAC complex)
  • INTERACTION
    DNA binding to naked DNA
    RNA
    small molecule
    protein POLE3, ACF1
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS