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FLASH GENE
Symbol CHRAC1 contributors: - updated : 29-08-2005
HGNC name chromatin accessibility complex 1
HGNC id 13544
Location 8q24.3      Physical location : 141.521.400 - 141.527.252
Synonym name histone-fold protein CHRAC15
Synonym symbol(s) YCL1, CHRAC15, CHARC1, CHARC15
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
histone fold domains
mono polymer heteromer , complex
HOMOLOGY
interspecies homolog to murine Chrac1
homolog to Drosophila iswi
Homologene
FAMILY
  • histone-fold superfamily
  • H2A-H2B subfamily
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • playing a role in heterochromatin dynamics
  • important for cell viability,developmental gene expression and chromosome structure
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the human ISWI chromatin remodelling complex with ACF1 and another histone-fold protein POLE3, component of the nucleolar chromatin remodeling complexes and of the chromatin remodeling and spacing factor RSF(ACF and CHRAC complex)
  • INTERACTION
    DNA binding to naked DNA
    RNA
    small molecule
    protein POLE3, ACF1
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS