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FLASH GENE

Symbol

CHP2

contributors: mct - updated : 11-05-2011

HGNC name	calcineurin B homologous protein 2
HGNC id

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p12.2      Physical location : 23.765.947 - 23.770.256

DNA

TYPE	functioning gene
STRUCTURE	4.30 kb     7 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_022097 7 - 2391 - 196 - 2003 12576672

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine     predominantly Homo sapiens   intestine small intestine     predominantly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	C-terminal region of CHP2 contains a nuclear export sequence (NES), that, with calcium, control the subcellular distribution of CHP2 (
	N-myristolated and include EF-hand motifs that bind Ca2+ (

HOMOLOGY

Homologene

FAMILY

calcineurin B homologous protein family

CATEGORY

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	serves as an obligatory subunit that is required both for supporting the basic activity and regulating the pH-sensing of SLC9A1 via interactions between distinct parts of these proteins )
	required for histone H3 lysine 14 (H3K14) deacetylation, and mediates transcriptional repression by limiting RNA polymerase II access to heterochromatin
	involved in transcriptional silencing at heterochromatic regions (

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	associates with the histone histone deacetylase complex, is required for histone H3 lysine 14 (H3K14) deacetylation, and mediates transcriptional repression by limiting RNA polymerase II access to heterochromatin
	interaction between CHP2 and SLC9A 1 (NHE1), two membrane proteins, is essential for protecting cells from serum deprivation-induced death

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   affects the biological behavior of ovarian cancer cell line OVCAR3 and is one of key mechanisms for ovarian carcinoma progression (

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     may be an attractive target for biological anticancer therapy

ANIMAL & CELL MODELS