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FLASH GENE
Symbol CHORDC1 contributors: mct - updated : 11-05-2011
HGNC name cysteine and histidine-rich domain (CHORD)-containing, zinc binding protein 1
HGNC id 14525
Location 11q14.2      Physical location : 89.933.596 - 89.956.532
Synonym name chord domain-containing protein 1
Synonym symbol(s) CHP1, Morgana
DNA
TYPE functioning gene
STRUCTURE 22.94 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 3343 - 313 - 2005 15642353
11 - 3400 - 332 - 2005 15642353
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Hearing/Equilibriumearinnercochlea highly
Nervousnerve   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a cysteine and histidine rich domain
  • two CHORD domains (I and II)
  • one CS domain (a domain shared by CHORD-containing proteins and SGT1)
  • HOMOLOGY
    interspecies homolog to CHORD containing C.elegans gene
    intraspecies homolog to melusin (ITGB1BP)
    Homologene
    FAMILY
    CATEGORY chaperone/stress , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • Hsp90-interacting protein
  • behaves like an HSP90 co-chaperone and possesses an independent molecular chaperone activity towards denatured proteins
  • potential involvement in natural protective mechanisms
  • appears to prevent both centrosome amplification and tumorigenesis
  • controls genomic stability by regulating the centrosome cycle via ROCK2
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Zn2+
    protein binds to the ATPase domain of Hsp90
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS