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FLASH GENE
Symbol CHN2 contributors: mct - updated : 30-10-2017
HGNC name chimerin (chimaerin) 2
HGNC id 1944
Location 7p14.3      Physical location : 29.234.120 - 29.553.943
Synonym name
  • beta chimerin
  • Rho GTPase-activating protein 3
  • Synonym symbol(s) RHOGAP3, ARHGAP3, BCH, MGC138360, BCH-3
    DNA
    TYPE functioning gene
    STRUCTURE 367.79 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • in promoter, alternative transcription start sites (TSSs), rather than alternative splicing, controls the generation of beta2- and beta3-chimaerins
  • MAPPING cloned Y linked N status confirmed
    Physical map
    LOC392011 7 similar to peptidylprolyl isomerase A LOC392986 7 similar to Triosephosphate isomerase (TIM) LOC392788 7 similar to mitogen-activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2, p45; MAP kinase kinase 2; MAPK/ERK kinase 2; dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2 CREB5 7p15 cAMP responsive element binding protein 5 MGC50844 7q32.3 hypothetical protein MGC50844 LOC392789 7 LOC392789 SMO 7q31 smoothened homolog (Drosophila) KIAA0828 7q32.3 KIAA0828 protein KIAA0644 7p21-p15.1 KIAA0828 protein CPVL 7p15-p14 carboxypeptidase, vitellogenic-like KIAA1170 7q32.3 KIAA1170 protein LOC392649 7 LOC392649 CHN2 7p15.3 chimerin (chimaerin) 2 NRF1 7q32 nuclear respiratory factor 1 KIAA0644 7p21-p15.1 nuclear respiratory factor 1 CPVL 7p15-p14 carboxypeptidase, vitellogenic-like UBE2H 7q32 ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast) LOC389475 7 LOC389475 CHN2 7p15.3 chimerin (chimaerin) 2 LOC222171 7p15.1 hypothetical protein LOC222171 NIPA 7q32.3 nuclear interacting partner of anaplastic lymphoma kinase (ALK) LOC392650 7 LOC392650 KIAA0265 7q32.3 KIAA0265 protein LOC392790 7 LOC392790 FLJ14803 7q32.3 hypothetical protein FLJ14803 LOC136263 7q32.3 LOC136263 CPA2 7q32 carboxypeptidase A2 (pancreatic) LOC222171 7p15.1 hypothetical protein LOC222171 CPA4 7q32 carboxypeptidase A4 SES1 7p14.3-p14.1 secernin 1 CPA5 7q32 carboxypeptidase A5 LOC389476 7 LOC389476 CPA1 7q32 carboxypeptidase A1 (pancreatic) FKBP14 7p15.3 FK506 binding protein 14, 22 kDa TSGA14 7q32 testis specific, 14 FAPP2 7p21-p11.2 phosphoinositol 4-phosphate adaptor protein-2 MEST 7q32 mesoderm specific transcript homolog (mouse) COPG2 7q32 coatomer protein complex, subunit gamma 2 Ells1 7p15.1 hypothetical protein Ells1 SES1 7p14.3-p14.1 secernin 1 LOC223082 7p15.1 zinc finger/RING finger 2 TSGA13 7q32 testis specific, 13
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2880 - 287 - 2001 11278894
    5 - 2703 - 228 - 2001 11278894
    6 - 2841 - 274 - 2001 11278894
    5 - 2799 - 260 - 2001 11278894
    5 - 2771 - 197 - 2001 11278894
    6 - 2877 - 286 - 2001 11278894
    13 - 3216 - 453 - 2001 11278894
    12 - 3405 - 4300 - 2001 11278894
    14 - 3500 - 481 - 2001 11278894
    14 - 3286 - 543 - 2001 11278894
    7 - 2843 - 332 - 2001 11278894
    13 - 3447 53 468 - 2001 11278894
    7 - 2742 - 241 - 2001 11278894
    14 - 1680 - 543 in epididymis, plasma blood leucocytes, spleen, and thymus 2014 24430297
  • has a novel N-terminal domain that is encoded by two unique exons located 48 kb upstream from the beta2-chimaerin open reading frame
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Hearing/Equilibriumear   highly
    Nervousbrainhindbraincerebellum highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal SH2 domain, SH2 domain possibly involved in interactions with phosphotyrosine proteins
  • a GAP domain and the phospho ester-binding region
  • C-terminal catalytic Rac-GAP domain
  • secondary structure
  • N-terminal region of the protein forms a 33 AA alpha-helix that rests against the lipid binding site in the C1 domain and occludes the Rac interaction surface in the GAP domain
  • HOMOLOGY
    intraspecies homolog to CHN1
    Homologene
    FAMILY
  • chimaerin Rac-GAP family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • GTPase activating protein for the ras-related p21rac
  • DAG (diacylglycerol) receptor
  • playing a role in T-cell receptor signaling
  • negatively controls many Rac-dependent pathophysiological events including tumor development
  • provides a novel, diacylglycerol-dependent mechanism for Rac regulation in T cells, playing a functional role in Rac-mediated cytoskeletal remodeling
  • GTPase-activating proteins that inactivate the GTP-hydrolase RAC1 in a diacylglycerol-dependent manner
  • inactivating Rac1 in response to EPHA1 stimulation (Takeuchi 2009)
  • mediates the EphA receptor-dependent regulation of cell migration (Takeuchi 2009)
  • a key element of proximal insulin signaling
  • is required for SEMA3F-dependent presynaptic pruning but it is not essential for SEMA3F-mediated hippocampal dentate gyrus (DG) axon repulsion
  • important regulator of the small GTPase Rac
  • plays an important role in adipogenesis and chemotaxis of the innate immune system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to EPHA2 and EPHA4
  • SEMA3F can induce CHN2 activation, and CHN2 is required for SEMA3F-dependent inhibition of Rac-GTP levels and does not significantly affect levels of activated CDC42
  • cell & other
    REGULATION
    activated by EPHA receptors (Takeuchi 2009)
    Other is negatively regulated by PRKCD-mediated phosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    was shown to result in decreased gene expression in patient-derived adipose tissue
    constitutional     --other  
    haploinsufficiency for INSR and CHN2 associated with severe insulin resistance and intrauterine growth deficiency
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidates for the downmodulation of RAC1 in T-lymphocytes
    Marker
    Therapy target
    ANIMAL & CELL MODELS