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FLASH GENE
Symbol CHMP6 contributors: mct - updated : 20-06-2018
HGNC name chromatin modifying protein 6
HGNC id 25675
Location 17q25.3      Physical location : 78.965.640 - 78.973.932
Synonym name
  • charged multivesicular body protein 6
  • vacuolar protein sorting 20
  • Synonym symbol(s) FLJ11749, VPS20
    DNA
    TYPE functioning gene
    STRUCTURE 8.29 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1678 - 201 - 2004 14583093
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Reproductivefemale systemuteruscervix highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal fragments of all ESCRT-III proteins, including CHMP2A, CHMP1B, VPS24, CHMP4A, CHMP6, and CHMP5, activated VPS4A suggesting that it disassembles ESCRT-III heteropolymers by affecting each component protein
  • HOMOLOGY
    interspecies ortholog to yeast Vps20
    Homologene
    FAMILY
  • SNF7 family
  • chromatin-modifying protein/charged multivesicular body protein (CHMP) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • required for multivesicular bodies (MVBs)
  • formation and sorting of endosomal cargo proteins into MVBs
  • acting as an acceptor for ESCRT-II on endosomal membranes and regulating cargo sorting
  • might be a novel regulator involved in both oncosis and apoptosis
  • with CHMP4C, CHMP4A, CHMP4B, VPS24, are sufficient to detach intralumenal vesicles
  • CHMP6 and VPS4A mediate the recycling of RAS to the plasma membrane to promote growth factor signaling
  • active role for ESCRT-II and CHMP6 in ESCRT-mediated abscission
  • during luminal vesicle formation at endosomes, the ESCRT-II complex and the ESCRT-III subunit vacuolar protein sorting CHMP6 play a specific role in regulating assembly of ESCRT-III filaments, which promote vesicle scission
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the endosomal sorting required for transport complex III (ESCRT-III), at least composed of CHMP1A, CHMP1B, CHMP2A, CHMP2B, CHMP3/VPS24, CHMP4A/SHAX2, CHMP4B/SHAX1, CHMP4C/SHAX3, CHMP5/SNF7DC2 and CHMP6
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with EAP20, ELOF1, DREV1
  • CHMP6 and VPS4A bound to NRAS but not KRAS
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS