basic FUNCTION
| required for multivesicular bodies (MVBs) |
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formation and sorting of endosomal cargo proteins into MVBs |
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acting as an acceptor for ESCRT-II on endosomal membranes and regulating cargo sorting |
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might be a novel regulator involved in both oncosis and apoptosis |
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with CHMP4C, CHMP4A, CHMP4B, VPS24, are sufficient to detach intralumenal vesicles |
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CHMP6 and VPS4A mediate the recycling of RAS to the plasma membrane to promote growth factor signaling |
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active role for ESCRT-II and CHMP6 in ESCRT-mediated abscission |
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during luminal vesicle formation at endosomes, the ESCRT-II complex and the ESCRT-III subunit vacuolar protein sorting CHMP6 play a specific role in regulating assembly of ESCRT-III filaments, which promote vesicle scission |