Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CHMP4A contributors: mct - updated : 05-11-2010
HGNC name chromatin modifying protein 4A
HGNC id 20274
Location 14q12      Physical location : 24.678.788 - 24.683.185
Synonym name
  • Snf7 homologue associated with Alix 2
  • chromosome 14 open reading frame 123
  • vacuolar protein sorting 7-1
  • charged multivesicular body protein 4a
  • Synonym symbol(s) HSPC134, C14orf123, SNF7-1, Shax2, MGC142093, MGC142095, CHMP4B, SNF7, VPS32A, FLJ61658
    DNA
    TYPE functioning gene
    STRUCTURE 4.57 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1505 - 265 - 2004 14583093
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary  highly
     male systemprostate  highly
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal fragments of all ESCRT-III proteins, including CHMP2A, CHMP1B, VPS24, CHMP4A, CHMP6, and CHMP5, activated VPS4A suggesting that it disassembles ESCRT-III heteropolymers by affecting each component protein
  • HOMOLOGY
    Homologene
    FAMILY
  • family of small coiled-coil proteins named CHMP
  • chromatin-modifying protein/charged multivesicular body protein (CHMP) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • localize to kinetochores
  • basic FUNCTION
  • implicated in playing roles in multivesicular body sorting
  • required for multivesicular bodies (MVBs)
  • with CHMP4B, form novel membrane-attached filaments that can promote or stabilize negative curvature and outward budding
  • with CHMP6, CHMP4C, CHMP4B, VPS24, are sufficient to detach intralumenal vesicles
  • could increase the expression of HIF1A protein under normoxic condition, and enhance the transcription level of AK3, which is one of the target genes of HIF1A
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    ESCRT-III (CHMP) proteins pathhway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HIV1-p6 Gag domain and inhibitng viral budding
  • interaction with CC2D1A, TTC19, CDC2L5
  • interacting with farnesylated Bro1 domain-containing protein BROX
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS