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FLASH GENE
Symbol CHMP2A contributors: mct - updated : 05-11-2010
HGNC name chromatin modifying protein 2A
HGNC id 30216
Location 19q13.43      Physical location : 59.062.933 - 59.066.486
Synonym name
  • charged multivesicular body protein 2a
  • vacuolar protein sorting 2-1
  • putative breast adenocarcinoma marker BC-2
  • putative breast adenocarcinoma marker (32kD)
  • VPS2 homolog A (S. cerevisiae)
  • Synonym symbol(s) BC-2, BC2, CHMP2, VPS2, VPS2A, hVps2-1
    DNA
    TYPE functioning gene
    STRUCTURE 3.55 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 926 - 222 - 2006 16730941
    6 - 928 - 222 - 2006 16730941
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Hearing/Equilibriumearinnercochlea highly
    Skin/Tegumentskin   highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal fragments of all ESCRT-III proteins, including CHMP2A, CHMP1B, VPS24, CHMP4A, CHMP6, and CHMP5, activated VPS4A suggesting that it disassembles ESCRT-III heteropolymers by affecting each component protein
  • HOMOLOGY
    Homologene
    FAMILY
  • SNF7 family
  • chromatin-modifying protein/charged multivesicular body protein (CHMP) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • required for multivesicular bodies (mvbs) formation and sorting of endosomal cargo proteins into mvbs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    ESCRT-III (CHMP) proteins pathhway
    a component
  • component of the endosomal sorting required for transport complex III (ESCRT-III), at least composed of CHMP1A, CHMP1B, CHMP2A, CHMP2B, CHMP3/VPS24, CHMP4A/SHAX2, CHMP4B/SHAX1, CHMP4C/SHAX3, CHMP5/SNF7DC2 and CHMP6
  • with VPS24, copolymerized in solution, and their membrane targeting was cooperatively enhanced on planar lipid bilayers
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with EIF2B5, NOL4, TTC19
  • binding between VTA1 and ESCRT-III proteins (CHMP1B, CHMP2A, VPS24) that is likely to complement VTA1 previously described ability to regulate VPS4 activity
  • AP1G2 specifically interacts with the ESCRT subunits VPS28 and CHMP2A
  • interactions between CDCA8 and CHMP2A, CHMP4B, CHMP4C, and CHMP6
  • strong interactions of MITD1 with CHMP1B, CHMP2A, and IST1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS