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FLASH GENE
Symbol CHMP1B contributors: mct - updated : 05-11-2010
HGNC name chromatin modifying protein 1B
HGNC id 24287
Location 18p11.21      Physical location : 11.851.388 - 11.854.447
Synonym name
  • chromosome 18 open reading frame 2
  • vacuolar protein sorting 46-2
  • CHMP1.5 protein
  • charged multivesicular body protein 1B
  • Synonym symbol(s) C18orf2, CHMP1.5, Vps46-2, C10orf2, Vps46B
    DNA
    TYPE functioning gene
    SPECIAL FEATURE gene in gene
    text embedded in exon 5 of the GNAL gene in the same orientation
    STRUCTURE 3.06 kb     1 Exon(s)
    text structure intronless
    MAPPING cloned Y linked N status provisional
    regionally located in a region of LOH in tumors of lung, brain, breast (see TSG18B)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 3060 22.1 199 - 2001 11474171
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary   
    Nervousbrain    
     nerve    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain, umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal half bound the microtubule-interacting and transport (MIT) domain of VPS4A and spastin
  • C-terminal fragments of all ESCRT-III proteins, including CHMP2A, CHMP1B, VPS24, CHMP4A, CHMP6, and CHMP5, activated VPS4A suggesting that it disassembles ESCRT-III heteropolymers by affecting each component protein
  • HOMOLOGY
    interspecies ortholog to murine C18orf2
    intraspecies homolog to PRMS1 in a +1 reading frame
    Homologene
    FAMILY
  • chromatin-modifying protein/charged multivesicular body protein (CHMP) family
  • SNF7 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • ESCRT-III protein, required for multivesicular bodies (MVBs)
  • putatively involved in development and in membrane traffick events
  • formation and sorting of endosomal cargo proteins into MVBs
  • required for recruitment of the MIT domain–containing protein spastin, a microtubule-severing enzyme, to the midbody
  • CHMP1B and IST1 directly interacted with a tandem repeat of MIT domains of CAPN7 and autolytic activity of CAPN7 was enhanced by IST1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    ESCRT-III (CHMP) proteins pathhway
    a component
  • component of the endosomal sorting required for transport complex III (ESCRT-III), at least composed of CHMP1A, CHMP1B, CHMP2A, CHMP2B, CHMP3, CHMP4A/SHAX2, CHMP4B, CHMP4C, CHMP5 and CHMP6
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with spastin, SUCLG1, SSRP1, RASSF7, CNOT10, ASCC3L1, RAB11A
  • binding between VTA1 and ESCRT-III proteins (CHMP1B, CHMP2A, VPS24) that is likely to complement VTA1 previously described ability to regulate VPS4 activity
  • CHMP1B and IST1 directly interacted with a tandem repeat of MIT domains of CAPN7 and autolytic activity of CAPN7 was enhanced by IST1
  • strong interactions of MITD1 with CHMP1B, CHMP2A, and IST1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS