SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
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| intracellular,nuclear envelope,matrix attachement regions
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text
| speckled nuclear localization of endogenous CHMP1A |
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basic FUNCTION
| required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs |
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also involved in chromosome condensation |
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plays a role in stable gene silencing within the nucleus |
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tumor suppressor, especially in pancreas and regulates tumor growth potentially through TP53 signaling pathway |
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regulates tumor growth partly through ATM signaling ( |
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plays a role in the cytoplasm in sorting proteins to the multivesicular body (MVB) |
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may serves as a critical link between cytoplasmic signals and BMI1-mediated chromatin modifications that regulate proliferation of central nervous system progenitor cells |
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possible role for CHMP1A in mediating BMI1-directed epigenetic silencing at the CDKN2A promoter but not at the ARF promoter |
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is a potentially crucial link between cytoplasmic signals and the global regulation of stem cells via the Polycomb complex |
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is required for progenitor proliferation in mouse cortex and cerebellum and progenitor maintenance in human cerebral organoids |
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