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FLASH GENE
Symbol CHKA contributors: mct - updated : 20-10-2012
HGNC name choline kinase alpha
HGNC id 1937
Location 11q13.2      Physical location : 67.820.327 - 67.888.858
Synonym name
  • CHETK-alpha
  • ethanolamine kinase
  • Synonym symbol(s) CKI, CHK, Chokalpha
    EC.number 2.7.1.32/ 2.7.1.82
    DNA
    TYPE functioning gene
    STRUCTURE 68.53 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2679 - 439 - 2010 19915674
    CHOKalpha2
    12 - 2733 - 457 - 2010 19915674
  • CHOKapha1
  • present a dual choline/ethanolamine kinase role, suggesting the involvement of each ChoK isoform in distinct biochemical pathways
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Reproductivefemale systembreast   
     male systemprostate   
    Respiratorylung    
    cell lineage
    cell lines breast cancer, colon cancer, lung cancer, prostate cancer
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to murine Chk
    homolog to rattus Chka
    Homologene
    FAMILY
  • choline/ethanolamine kinases family
  • ChoK family of proteins
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalysing the phosphorylation of choline and ethanolamine by ATP
  • may be involved in human carcinogenesis
  • having a regulatory role in phosphatidylcholine pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SRC-dependent link between CHKA and EGFR, which contributes to the regulation of cell proliferation and tumorigenesis
  • cell & other
    REGULATION
    activated by Ras proteins through Ral-GDS and PI3K
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer, colon cancer, lung cancer, prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • disruption of murine Chka leads to embryonic lethality