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FLASH GENE

Symbol

CHID1

contributors: KTN/npt - updated : 22-01-2009

HGNC name	chitinase domain containing 1
HGNC id	28474

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11p15.5      Physical location : 867.859 - 915.058
Synonym name	stabilin-1-interacting chitinase-like protein
Synonym symbol(s)	SI-CLP, GL008, PSEC0104, SB139, MGC3234, FLJ42707

DNA

TYPE	functioning gene
STRUCTURE	42.43 kb     13 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

Map	pter - CHID1 - D11S1363 - D11S4177 - cen
Authors	UCSC (2009)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 3558 44.8 393 - - encoding the same protein than variants 2 and 3 variant 2 - - 3448 44.8 393 - - differing in the 5' UTR compared to variant 1 encoding the same protein than variants 1 and 3 variant 3 13 - 3344 44.8 393 - - differing in the 5' UTR compared to variant 1 encoding the same protein than variants 1 and 2 variant 4 - - 3419 47.5 418 - - differing in the 5' UTR compared to variant 1 containing an alternate in-frame exon in the 5' coding region compared to variant 1 variant 5 - - 3252 41.5 362 - - differing in the 5' UTR compared to variant 1 lacking an alternate in-frame exon in the central coding region compared to variant 1

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune macrophage

cell lineage	cells of monocytic, T, B and epithelial origin (Kzhyshkowska 2006)
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to rattus Chid1 (89.3 pc)
	homolog to murine Chid1 (87.9 pc)

Homologene

FAMILY

glycosyl hydrolase 18 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,lysosome

basic FUNCTION

acting as a chitinase

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

chitin catabolic process

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with STAB1 (Kzhyshkowska 2006)

cell & other

REGULATION

induced by

interleukin-4 and dexamethasone in the macrophages (Kzhyshkowska 2006)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS