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FLASH GENE
Symbol CHIC2 contributors: mct/npt - updated : 07/11/2008
HGNC name cysteine-rich hydrophobic domain 2
HGNC id 1935
Location 4q12      Physical location : 54.875.957 - 54.930.788
Synonym name BrX-like translocated in leukemia
Synonym symbol(s) BTL, BRX, MGC21173
DNA
TYPE functioning gene
STRUCTURE 54.83 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1151 - 165 - Cools (2001)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Reproductivefemale systembreastmammary gland highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • cystein-rich hydrophobic domain
  • HOMOLOGY
    Homologene
    FAMILY
  • CHIC family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    ETV6 in acute myelod leukemias with a t(4;12) (q11-q12;p13)
    tumoral   translocation   protein chimeric
    in a chromosomal translocation t(4;12)(q11;p13) occurring in acute myeloid leukemias
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS