basic FUNCTION
| capable of cleaving artificial chitin-like substrates as well as crab shell chitin and chitin as present in the fungal cell wall |
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secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by pulmonary epithelial cells (Hartl 2008) |
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may play a role in digestion and/or defense |
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being an important mediator of IL-13-induced responses in Th2-dominated disorders such as asthma |
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plays an important role in the pathogenesis of Th2-mediated diseases and antiparasite responses (Hartl 2009) |
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protects airway epithelial cells from Fas ligand- and growth factor withdrawal-induced apoptosis, but regulates epithelial cell apoptosis via a chitinolytic-independent mechanism (Hartl 2009) |
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CHIA, CHIT1, CHI3L1, CHI3L2 and CHID1 exert important biological roles in the monocyte lineage and chronic inflammatory diseases |
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CHIA, CHI3L2 and CHID1 resulted unchanged during osteoclast differentiation, whereas CHIT1 and CHI3L1 increased significantly |