SUBCELLULAR LOCALIZATION
| extracellular
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| intracellular
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| intracellular,cytoplasm,organelle,lumen
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,cytosolic,inclusion
|
| intracellular,cytoplasm,cytosolic,granule
|
text
| found in secretory granules and in the lumen of the endoplasmic reticulum |
basic FUNCTION
| acidic protein of secretory granules, binding calcium and aggregating in its presence |
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involved in the transcription control in the nucleus |
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low affinity calcium (Ca2+) storage proteins found in many cell types, most often associated with secretory granules of secretory cells but also with the endoplasmic reticulum (ER) lumen of these cells |
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may play an important modulatory role in the control of Ca2+ release from the ER, and could influence the pattern of INSP3-mediated Ca2+ release |
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may act as a susceptibility gene and modifier of onset in ALS (consistent with the emerging view that dysfunction of the secretory pathway may contribute to increased vulnerability of motor neurons) |
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CHGB, like CHGA, is a highly efficient system directly involved in monoamine accumulation and in the kinetics of exocytosis from large dense core secretory vesicles |
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CHGA, CHGB are involved in granulogenesis and protein sorting |
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essential for adequate secretion of islet hormones |
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CHGA, CHGB are regulators of vesicle cargo and exocytosis |
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CHGA, CHGB are the main soluble proteins in the large dense core secretory vesicles (LDCVs) found in aminergic neurons and chromaffin cells |
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involved in defining the magnitude and initiation site of calcium signals |
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role in the maintenance and modulation of calcium signaling, as well as in granule biogenesis |