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FLASH GENE
Symbol CHERP contributors: mct - updated : 24-04-2013
HGNC name calcium homeostasis endoplasmic reticulum protein
HGNC id 16930
Location 19p13.11      Physical location : 16.628.699 - 16.653.263
Synonym name
  • human ERPROT 213-21 mRNA
  • SR-related CTD associated factor 6
  • CHERP protein
    • Synonym symbol(s) DAN16, SCAF6, ERPROT213-21, SRA1
    DNA
    TYPE functioning gene
    STRUCTURE 24.56 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 4105 104 916 - 2011 21454501
    - - - 6400 128 - cardiac and skeletal muscle 2011 21454501
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   predominantly
     thymus   highly
    Reproductivefemale systemuteruscervix highly
     female systemovary  highly
     female systemplacenta  highly
    Respiratorylung   highly
    Urinarybladder   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • G-patch domain
  • glycine-rich nucleic binding domain
  • putative transmembrane domain
  • multiple consensus phosphorylation sites
  • a polyglutamine tract of 12 repeats and regions of imperfect tryptophan and histidine octa and nona -peptide repeats
    • HOMOLOGY
    interspecies ortholog to rattus Cherp_predicted
    ortholog to murine Cherp
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nuclear envelope
    basic FUNCTION
  • playing a role in calcium homeostasis, growth and proliferation
  • involved in negative regulation of cell proliferation
  • involved in regulation of nuclear pre-mRNA protein
  • important component of the ER Ca(2+)-mobilizing system in cells, and its loss impairs Ca(2+)-dependent biochemical pathways and progression through the cell cycle
  • acts as a direct cytoplasmic regulator of IP(3)Rs and RyRs and in the nucleus to impact cellular proliferation by regulating the function of the U2 snRNA spliceosomal complex
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    text nervous system development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • CHERP is an RYR1 interacting protein that may be involved in the regulation of excitation-contraction coupling
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS