SUBCELLULAR LOCALIZATION
| intracellular
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
|
| intracellular,nucleus,nucleoplasm,nuclear bodies,PML
|
| intracellular,nucleus,chromatin/chromosome,kinetochore
|
text
| binds centrosomes and arrests mitosis only after activation by ATM and ATR in response to DNA damage |
|
localizes to kinetochores |
basic FUNCTION
| key cell cycle control gene encoding a pluripotent kinase that can cause arrest or apoptosis in response to unrepaired DNA damage |
|
playing a central role in DNA damage response pathways |
|
preventing cells containing damage DNA from entering mitosis |
|
may have a role in meiosis |
|
stabilizing TP53 by phosphorylation on serine 20 leading to cell cycle arrest in G1 in response to DNA damage |
|
phosphorytating BRCA1 on serine 988,after DNA damage |
|
nuclear phosphokinase responsible for the nuclear stabilization of TTC5 |
|
functions to maintain genome integrity after radiation-induced damage and has important implications for the use of Chk2 inhibitors as adjuvant cancer therapy |
|
important transducer of DNA damage checkpoint signals, and its mutation contributes to hereditary and sporadic cancer |
|
mediates the induction of senescence in fibroblasts, but is dispensable for the induction of telomere dysfunction checkpoints at the stem and progenitor cell level |
|
CHEK2 centrosomal binding does not require DNA damage, but varies according to cell cycle progression |
|
effector component of the ATM-dependent DNA damage response (DDR) pathway |
|
critical regulator of the cellular DNA damage repair response |
|
CHEK1 and CHEK2 cooperatively affect G1/S and intra-S phase checkpoints |
|
is an essential mediator of the cellular responses to as an essential mediator of the cellular responses to RITA (reactivation of TP53 and induction of tumor cell apoptosis) |
|
is a kinase that acts as a tumor suppressor gene |
|
is a DNA damage checkpoint protein important for the ATM-TP53 signaling pathway |
|
CHEK2 stabilizes TTK and phosphorylates AURKB-serine 331 to prevent mitotic exit when most kinetochores are unattached |
|
role for CHEK2 in the signaling of dysfunctional telomeres |
|
is a key component of the DNA damage response |
|
participates in several molecular processes involved in DNA structure modification and cell cycle progression |
|
activation of the checkpoint kinases CHEK1 and CHEK2 by DNA damage triggers cell cycle arrest and improved DNA repair, or apoptosis in case of excessive damage |
|
during mitosis, BRCA1 and its positive regulator CHEK2 are localized at centrosomes and are required for the regulation of microtubule plus end assembly, thereby ensuring faithful mitosis and numerical chromosome stability |