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FLASH GENE
Symbol CHD6 contributors: mct - updated : 03-10-2007
HGNC name chromodomain helicase DNA binding protein 6
HGNC id 19057
Location 20q12      Physical location : 40.031.169 - 40.247.133
Synonym symbol(s) KIAA1335, CHD5, RIGB
EC.number 3.6.1.-
DNA
TYPE functioning gene
STRUCTURE 216.00 kb     37 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   moderately
Endocrinethyroid   moderately
Lymphoid/Immunethymus   moderately
Reproductivefemale systembreastmammary gland highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two DNA binding chromodomains
  • a central helicase ATPase related SNF2 domain
  • a region with similarity to the Myb-DNA binding domain
  • a DEAH box
  • a DNA binding domain located at the C terminus
  • HOMOLOGY
    interspecies homolog to dog CHD6 (92.1 pc)
    homolog to chimpanzee CHD6 (99.8 pc)
    homolog to rattus Chd6 (88.6 pc)
    homolog to murine Chd6 (88.9 pc)
    Homologene
    FAMILY
  • CHD subfamily III
  • SNF2/RAD54 helicase family
  • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • having a DNA-dependent ATPase activity
  • may play a role in RNA polymerase II-mediated transcriptional processes
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text nervous system development
    PATHWAY
    metabolism
    signaling
    a component component of a chromatin remodeling complex
    INTERACTION
    DNA binding
    RNA
    small molecule nucleotide,
  • ATP
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS