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FLASH GENE
Symbol CHD1L contributors: mct - updated : 04-12-2017
HGNC name chromodomain helicase DNA binding protein 1-like
HGNC id 1916
Location 1q21.1      Physical location : 146.714.290 - 146.767.441
Synonym name amplified in liver cancer protein 1
Synonym symbol(s) CHDL, FLJ22530, ALC1
EC.number 3.6.4.12
DNA
TYPE functioning gene
STRUCTURE 122.96 kb     23 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
23 - 3023 - 897 - 2009 19661379
23 - 3008 - 784 - 2009 19661379
22 - 2929 - 797 - 2009 19661379
18 - 2506 - 616 - 2009 19661379
17 - 2424 - 693 - 2009 19661379
- - 3352 - 825 - 2009 19661379
- - 2873 - 825 - 2009 19661379
- - 2901 - 784 - 2009 19661379
- - 2558 - 745 - 2009 19661379
- - 2982 - 734 - 2009 19661379
- - 2565 - 616 - 2009 19661379
- - 2894 - 616 - 2009 19661379
- - 2925 - 616 - 2009 19661379
- - 2787 - 616 - 2009 19661379
- - 2851 - 616 - 2009 19661379
- - 2738 - 616 - 2009 19661379
- - 3007 - 616 - 2009 19661379
- - 2647 - 616 - 2009 19661379
- - 2819 - 616 - 2009 19661379
- - 2932 - 616 - 2009 19661379
- - 2640 - 616 - 2009 19661379
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis    Mus musculusAdult
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one helicase ATP-binding domain
  • one helicase C-terminal domain
  • one macro domain
  • HOMOLOGY
    interspecies homolog to murine Chd1l (87.5pc)
    homolog to rattus Chd1l (88.2pc)
    Homologene
    FAMILY
  • CHD family
  • SNF2/RAD54 family
  • SNF2 superfamily of ATPases
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • functioning to regulate chromatin during DNA repair (Ahel 2009)
  • nucleosome-repositioning enzyme that is targeted to sites of DNA damage through its interaction with PAR (Gottschalk 2009)
  • promotes cell proliferation and inhibits apoptosis
  • downregulating expression of TP53, CDKN1A, BAX, caspase 3 and upregulating CDK2 and CCNE1
  • oncogene that plays a role in HCC pathogenesis (Ma 2008)
  • plays a role in kidney development
  • its oncogenic role in tumorigenesis is through unleashed cell proliferation, G1/S transition and inhibition of apoptosis
  • promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors
  • is an important player in the fast kinetics of the NAD+- and ATP-dependent chromatin relaxation upon DNA damage
  • participates in chromatin-dependent processes, including transcriptional activation and DNA repair
  • is likely an intrinsic and novel regulator for spermatogonia or spermatogonial stem cells (SSCs) survival and self-renewal, and it exerts such regulation at least partially through a GDNF signaling pathway
  • CHD1L promotes neuronal differentiation of hESCs and may play an important role in nervous system development
  • is likely a unique base excision repair (BER) factor that functions in a chromatin context, most likely as a chromatin-remodeling enzyme
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the chromatin remodeling complex
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of CHD1L
  • TRIM33 plays a role in PARP-dependent DNA damage response and regulates CHD1L activity by promoting its timely removal from sites of DNA damage
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    frequently overexpressed in hepatomacellular carcinomas
    tumoral     --over  
    in human ovarian carcinomas and is a novel predictive biomarker for patients survival (pMID: 23020525)
    Susceptibility
    Variant & Polymorphism
    Candidate gene may be a new candidate gene for CAKUT
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    is a potential anti-metastasis target for therapeutic intervention in breast cancer
    ANIMAL & CELL MODELS