Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CHAF1A contributors: mct/npt - updated : 16-04-2008
HGNC name chromatin assembly factor 1, subunit A (p150)
HGNC id 1910
Location 19p13.3      Physical location : 4.402.659 - 4.443.393
Synonym name CAF-1 subunit A
Synonym symbol(s) CAF1, CAF-1, CAF1B, CAFA, CAF1P150, MGC71229, P150, CAF
DNA
TYPE functioning gene
STRUCTURE 40.00 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
APBA3 19p13.3 amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2) MRPL54 19p13.3 mitochondrial ribosomal protein L54 MGC15631 19p13.3 hypothetical protein MGC15631 MATK 19p13.3 megakaryocyte-associated tyrosine kinase KIAA1086 19p13.3 megakaryocyte-associated tyrosine kinase LOC388494 19 hypothetical gene supported by AL365406; BC034005 ATCAY 19p13.3 ataxia, cerebellar, Cayman type (caytaxin) ITGB1BP3 19p13.3 integrin beta 1 binding protein 3 DAPK3 19p13.3 death-associated protein kinase 3 EEF2 19p13.3 eukaryotic translation elongation factor 2 PIASY 19p13.3 protein inhibitor of activated STAT protein PIASy LOC387622 19 hypothetical gene supported by NM_020224 FBI1 MAP2K2 7q32 mitogen-activated protein kinase kinase 2 CREB3L3 19p13.3 cAMP responsive element binding protein 3-like 3 SIRT6 19p13.3 sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) KIAA1981 EBI3 19p13.3 Epstein-Barr virus induced gene 3 FLJ10374 19p13.3 hypothetical protein FLJ10374 SHD 19p13.3 src homology 2 domain-containing transforming protein D MGC23244 19p13.3 hypothetical protein MGC23244 FSD1 19p13.3 fibronectin type 3 and SPRY (spla, ryanodine) domain containing (with coiled-coil motif) 1 STAP2 19p13.3 signal-transducing adaptor protein-2 FLJ14981 19p13.3 hypothetical protein FLJ14981 SH3GL1 19p13.3 SH3-domain GRB2-like 1 CHAF1A 19p13.3 chromatin assembly factor 1, subunit A (p150) UBXD1 19p13 UBX domain containing 1 MGC2641 19p13.3 hepatoma-derived growth factor-related protein 2 FLJ20700 19p13.3 hypothetical protein FLJ20700 LOC388495 19 similar to Calphotin CG4795-PA LRG SEMA6B 19p13.3 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B MGC17791 19p13.3 hypothetical protein MGC17791 C19orf10 19p13.3 chromosome 19 open reading frame 10 DPP9 19p13.3 dipeptidylpeptidase 9 PGSF1 19p13.3 pituitary gland specific factor 1a FEM1A 19p13.3 fem-1 homolog a (C.elegans) TRIF 19p13.3 fem-1 homolog a (C.elegans) TIP47 LOC342959 19p13.3 similar to Hypothetical protein CBG18249 UHRF1 19p13.3 ubiquitin-like, containing PHD and RING finger domains, 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 3344 - 956 - Bethke (2008)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Endocrineadrenal gland   highly
Lymphoid/Immunelymph node   highly
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, G1, S, G2
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal PEST domain
  • HOMOLOGY
    interspecies homolog to murine Chaf1a
    Homologene
    FAMILY
    CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • playing an essential role in eukaryotic chromatin assembly during DNA replication
  • required for efficient S-phase progression in cells, and for coupling chromatin assembly with DNA replication
  • major regulator of chromatin assembly during DNA repair
  • key factor involved in histone deposition
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of the chromatin assembly factor-1 (CAF-1) complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • histone H3 and H4
  • with the replication kinase CDC7-DBF4
  • ASF1A is a highly conserved histone H3/H4 chaperone that synergizes with two other histone chaperones, CHAF1A and HIRA, in DNA synthesis-coupled and DNA synthesis-independent nucleosome assembly
  • ANGEL1 has been shown to interact with CHAF1A, which has deadenylase activity, suggesting that ANGEL1 may recruit CHAF1A in EIF4E complexes
  • cell & other
    REGULATION
    Other regulated by TSC1 and TSC2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to glioma
    Variant & Polymorphism SNP increasing the risk of glioma
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS