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FLASH GENE

Symbol

CHAD

contributors: mct - updated : 25-08-2014

HGNC name	chondroadherin
HGNC id	1909

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q21.33      Physical location : 48.541.853 - 48.546.227
Synonym name	chondroadherin proteoglycan
	cartilage leucine-rich protein
Synonym symbol(s)	SLRR4A
EC.number	1.1.1.35

DNA

TYPE	functioning gene
STRUCTURE	4.37 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001267 4 - 1712 NP_001258 38.3 359 - 2011 21127050

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Connective cartilage     highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol not specific chondrocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a potential signal peptide
	eleven leucine-rich repeats flanked by cysteine-rich regions
	four cysteine residues within its C terminal disulfide-bonded domain
	isolated C-terminal heparin-binding domain (HBD)4 of 13 amino acids was shown to stimulate bound chondrocytes to spread and to prominently increase attachment to integrins with the formation of focal adhesion complexes, and contributes to heparin binding

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY	small leucine-rich proteoglycan (SLRP) family
	leucine-rich repeat proteins family

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION	extracellular
text	extracellular matrix

basic FUNCTION	may be playing an mportant role in the regulation of chondrocyte growth and proliferation
	leucine-rich repeat protein known to mediate adhesion of isolated cells via the integrin ITGA2/ITGB1 and to interact with collagen
	chondroadherin interaction with cells may be central for maintaining the adult chondrocyte phenotype and cartilage homeostasis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

both chondroadherin and collagen interact with chondrocytes, partly via the same receptor, but give rise to different cellular responses

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS