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FLASH GENE
Symbol CGRRF1 contributors: - updated : 08-01-2004
HGNC name cell growth regulator with ring finger domain 1
HGNC id 15528
Location 14q22.1      Physical location : 54.976.586 - 55.005.332
Synonym name cell growth regulatory gene 19
Synonym symbol(s) CGR19
DNA
TYPE functioning gene
STRUCTURE 29.00 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell null (stem cell)
cell lineage
cell lines proliferative cells expressing TP53
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a ring zinc binding C3HC4 RING finger domain
HOMOLOGY
interspecies ortholog to rattus cell growth regulator
Homologene
FAMILY
CATEGORY regulatory , signaling growth factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • primary response gene expressed to moderate levels in functional p53 cells
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text negative regulator of cell proliferation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Zn2+
    protein
    cell & other
    REGULATION
    induced by TP53
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS