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FLASH GENE
Symbol CGNL1 contributors: mct - updated : 26-11-2018
HGNC name cingulin-like 1
HGNC id 25931
Location 15q21.3      Physical location : 57.668.704 - 57.842.920
Synonym name
  • junction-associated coiled-coil protein
  • paracingulin
    • Synonym symbol(s) FLJ14957, JACOP, KIAA1749, PCING
    DNA
    TYPE functioning gene
    STRUCTURE 112.74 kb     18 Exon(s)
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure a TATA-less promoter including a transcription initiator cap sequence and multiple DNA motifs that bind transcription factors
    MAPPING cloned Y linked N status provisional
    Map pter - CYP19A1 - TMOD3 - CGNL1 - qter
    Authors Shozu et al.(03)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 7235 160 1302 - 2004 15292197
    - - 7353 - 1302 - 2004 15292197
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Lymphoid/Immunespleen    
    Nervousbraindiencephalonamygdala  
     brainbasal nucleicorpus callosum  
     braindiencephalonthalamus  
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Muscularsmooth   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region containing a conserved ZIM (ZO-1-Interaction-Motif) sequence
    • HOMOLOGY
    interspecies homolog to murine Cgnl1
    Homologene
    FAMILY
    CATEGORY adaptor , chaperone/stress
    SUBCELLULAR LOCALIZATION plasma membrane,junction,tight
    plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytoskeleton,microfilament
    text
  • concentrated in the junctional complex in various types of epithelial and endothelial cells
  • Furthermore, in the liver and kidney, also distributed along non-junctional actin filaments
  • is peripherally localized in isolated cells, requires the integrity of the microtubule cytoskeleton to be stably anchored to junctions
  • localized in the cytoplasmic region of epithelial tight and adherens junctions
  • CGN, CGNL1 and PLEKHA7 are proteins localized in the cytoplasmic region of the apical junctional complex of vertebrate epithelial cells
    • basic FUNCTION
  • involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons
  • regulates the activity of RAC1 and RHOA GTPases by recruiting TIAM1 and ARHGEF2 to epithelial junctions
  • CGN and CGNL1 regulate Rho family GTPases by recruiting guanine nucleotide exchange factors to epithelial junctions
  • CGN1 and CGNL1 show a similar dynamic behaviour, but partially distinct localizations and functional interactions with the cytoskeleton, and are recruited independently to junctions
  • component of the macromolecular complex that links adherens junctions to microtubules, and PLEKHA7, and, to a lesser extent, TJP1, are required to recruit paracingulin to epithelial junctions efficiently
  • PLEKHA7, together with CNGL1, is part of a protein complex that links CDH1 to the microtubule cytoskeleton at AJs
  • functional relevance for CGNL1 as a defining factor in new vessel formation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a complex with the tight junction protein TJP1, and the globular head domain of paracingulin interacts directly with TJP1 through an N-terminal region containing a conserved ZIM (ZO-1-Interaction-Motif) sequence
  • forms a complex with PLEKHA7 and its interacting partner CTNND1, and the globular head domain of paracingulin interacts directly with a central region of PLEKHA7
  • SH3BP1 formed a complex with CGNL1/paracingulin, a junctional adaptor, and CD2AP, a scaffolding protein, and both were required for normal CDC42 signaling and junction formation
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulator of the activity of two small GTPases, RAC1 and RHOA, through the functional interaction with their respective activators, TIAM1 and ARHGEF2
  • associates with E-cadherin, CDH1
  • TJP1 and the adherens junction protein PLEKHA7 as paracingulin-binding proteins
  • one function of CGN and CGNL1 is to regulate the activity of Rho family GTPases at junctions through their direct interaction with guanidine exchange factors of RHOA and RAC1
  • CGN and CGNL1 control RHOA activation in epithelial cells by interacting with RHOA guanidine exchange factors
  • regulates vascular growth by promoting CDH5 association with the actin cytoskeleton, thereby stabilizing adherens junctions
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS