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FLASH GENE
Symbol CFP contributors: mct - updated : 29-11-2017
HGNC name complement factor properdin
HGNC id 8864
Corresponding disease
PFD properdin deficiency
Location Xp11.3-p11.23      Physical location : 47.483.612 - 47.489.704
Synonym name
  • properdin P factor, complement
  • properdin
  • complement factor P
    • Synonym symbol(s) BFD, PROPERDIN, PFC, PFD
    DNA
    TYPE functioning gene
    STRUCTURE 6.00 kb     10 Exon(s)
    MAPPING cloned Y linked Y status confirmed
    Map pter - DXS7 - DXS228 - MAOA - MAOB - UBE1 - ARAF - TIMP1 - DXS426 - CFP - ELK1 - TBC1D25 - GATA1 - DXS255 - DXS423 ,ALAS2 ,DXS674 ,DXS390 - cen
    Authors Coleman (93), Boyd (93)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1701 51 469 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • modular protein with distinct N and C terminal region
  • a central region
  • six tandem repeated motifs, related to the type I repeat sequence of thrombospondin
    • conjugated GlycoP
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • thrombospondin family
    • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • complement alternative pathway
  • stabilizing the alternative pathway C3 convertase
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MPO binds properdin directly, which then serves as a focus for alternative pathway (AP) activation
    • cell & other
  • can directly interact with neutrophil components
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PFD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS