SUBCELLULAR LOCALIZATION
| plasma membrane,junction
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,cytosolic,vesicle
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| intracellular,cytoplasm,cytoskeleton
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| intracellular,nucleus
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| intracellular,nuclear envelope
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text
| localization in lamellipodia and membrane ruffles, and can also accumulate in the tips and shafts of filopodia  |
basic FUNCTION
| actin-binding protein, depolymerisation factor of F-actin to G-actin |
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interfering with immunological synapse formation and T-cell activation |
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plays an essential role for the rapid turnover of actin filaments by severing and depolymerizing them  |
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actin-filament-severing activity of cofilin is critical for growth cone motility and neurite extension  |
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target for Tight junction permeability regulation in epithelial cells  |
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with CORO2A, are implicated as factors that can regulate a subset of focal-adhesion-turnover events  |
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responsible for the formation of the actin cytoskeleton and is indispensable for cell cycle control  |
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cofilin expression and its regulation of CDKN1B expression is important for the control of G(1) phase progression  |
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plays an important role in cortical cytoplasmic organization during embryo compaction  |
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cofilin expression and its regulation of CDKN1B expression is important for the control of G(1) phase progression  |
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major regulator of actin dynamics involved in the regulation of cell spreading and migration through its actin depolymerizing and severing activities  |
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ADF/cofilin-mediated actin dynamics regulated AMPA receptor (AMPAR) trafficking during synaptic potentiation  |
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temporally regulated ADF/cofilin activities function in postsynaptic modifications of receptor number and spine size during synaptic plasticity ( |
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its activation is required for FAS-stimulated formation of membrane protrusions and increased tumour cell invasion)  |
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FSCN1 and CFL1 act synergistically in filament severing  |
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cooperates with FSCN1 to disassemble filopodial actin filaments  |
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essential and conserved modulator of actin dynamics in eukaryotic cells  |
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CFL1 and VANGL2 cooperate likely in the initiation of planar cell polarity in the embryo  |
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Cofilin/actin rod formation by dysregulation of CFL1 activity is a central initial step in neurodegeneration  |
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CFL1 is required for the activation of apical actomyosin required for neural tube closure  |
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actin dynamic reassembly and CFL1 phosphorylation loop is involved in the control of stromal (skeletal) stem cells (hMSCs) proliferation and osteoblasts differentiation  |
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control actin stress fibers, nuclear integrity, and cell survival  |
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key protein in the regulation of actin dynamics and migration  |
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actin-binding protein and a major actin depolymerization factor in the central nervous system (CNS)  |
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CFL1 induces Epithelial-mesenchymal transition (EMT) by promoting cytoskeletal rearrangement 5) |
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actin filament length regulators CFL1, CAPZB and DIAPH1 regulate mitotic cortex thickness and both increasing and decreasing thickness decreases tension in mitosis  |
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optogenetic regulation of CEFL1 revealed its critical role for controlling timing, turnover and dynamics of F-actin assembly inside daughter cell nuclei  |
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CFL1 and WDR1 are evolutionally conserved proteins that cooperatively sever actin filaments  |