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FLASH GENE
Symbol CFDP1 contributors: mct - updated : 28-06-2018
HGNC name craniofacial development protein 1
HGNC id 1873
Location 16q23.1      Physical location : 75.327.608 - 75.467.387
Synonym name
  • phosphoprotein (Bucentaur)
  • centromere protein 29
  • Synonym symbol(s) BCNT, P97, CP27, SWC5, Yeti, BUCENTAUR, CENP-29
    DNA
    TYPE functioning gene
    STRUCTURE 139.78 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D16S512 - CTRB1 - CFDP1- D16S515 - qter
    Authors Gene Map (98)
    Physical map
    LOC388292 16 similar to NPIP-like protein LOC388293 16 similar to nuclear pore complex interacting protein LOC388294 16 similar to secretory protein LOC348174 LOC388295 16 LOC388295 GLG1 16q22-q23 golgi apparatus protein 1 FLJ10520 16q22.3 hypothetical protein FLJ10520 FLJ34389 16q22.3 hypothetical protein FLJ34389 FA2H 16q23 fatty acid 2-hydroxylase FLJ12270 16q22.3 hypothetical protein FLJ12270 ZNRF1 16q22.3 zinc and ring finger protein 1 LDHD 16q22.3 lactate dehydrogenase D ZFP1 16q22.3 zinc finger protein 1 homolog (mouse) CTRB1 16q23.1-q23.2 chymotrypsinogen B1 LOC390741 16 similar to 40S ribosomal protein S4, Y isoform LOC339102 16q22.3 similar to Chymotrypsinogen B precursor LOC146599 16q22.3 hypothetical LOC146599 BCAR1 16q22-q23 breast cancer anti-estrogen resistance 1 LOC388296 16 LOC388296 CFDP1 16q22.2-q22.3 craniofacial development protein 1 LOC388297 16 similar to hypothetical protein - fruit fly (Drosophila melanogaster) transposon pogoR11 LOC124491 16q22.3 LOC124491 CHST6 16q22 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 LOC388298 16 LOC388298 CHST5 16q23.1 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 GABARAPL2 16q22.3-q24.1 GABA(A) receptor-associated protein-like 2 ADAT1 16q22.2-q22.3 adenosine deaminase, tRNA-specific 1 KARS 16q23-q24 lysyl-tRNA synthetase TERF2IP 16q22.3 telomeric repeat binding factor 2, interacting protein LOC342409 16q23.1 similar to Hypothetical protein MGC67567 LOC124496 16q23.1 similar to ATP synthase B chain, mitochondrial precursor LOC124321 16q23.1 similar to ribosomal protein L18; 60S ribosomal protein L18
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1281 - 299 - 2017 28367969
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveliver    
     pharynx   highly
     tooth    
    Endocrineneuroendocrinepituitary  predominantly
    Hearing/Equilibriumearinner  highly
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandular  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text periosteum of developing bones
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • lacking the 840bp repetitive sequence
  • one of the intramolecular repeats, present in bovine BCNT
  • highly conserved C-terminal domain
  • HOMOLOGY
    interspecies homolog to murine Cp27
    homolog to drosophila Yeti
    Homologene
    FAMILY evolutionarily conserved Bucentaur (BCNT) family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,kinetochore
    basic FUNCTION
  • involved in early vertebrate development that features a distinct expression pattern in developing tooth organs
  • unanticipated role of CFDP1 in chromatin organization
  • essential protein required for chromatin/chromosome organization and function
  • linked to craniofacial development and osteogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • homodimerization mediated by the BCNT domain is integral to the chromatin functions of BCNT proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NFYC transcription factor is the CCAAT activator controlling transactivation of the CFDP1 promoter
  • CFDP1, Sec23 homolog A (SEC23A), and nuclear receptor binding SET domain protein 1 (NSD1), contain consensus GTF2I binding sites in their proximal promoters
  • CFDP1 binds to chromatin and interacts with subunits of the SRCAP chromatin remodeling complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS