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FLASH GENE
Symbol CFD contributors: - updated : 13-03-2006
HGNC name complement factor D (adipsin)
HGNC id 2771
Location 19p13.3      Physical location : 859.664 - 863.608
Synonym name
  • D component of complement (adipsin)
  • properdin factor D
  • C3 convertase activator
  • Synonym symbol(s) DF, PFD, ADN
    EC.number 3.4.21.46
    DNA
    TYPE functioning gene
    STRUCTURE 3.00 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectiveadipose   
    cells
    SystemCellPubmedSpeciesStageRna symbol
     adipocyte
    Blood/Hematopoieticmonocyte
    Digestivehepatocyte
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide from the 1st to the 23th aa
  • a peptidase S1 domain
  • isoforms Precursor a mature form made of 227 aa with a 24.4kDa
    HOMOLOGY
    Homologene
    FAMILY peptidase S1 family
    CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
    text secreted protein
    basic FUNCTION
  • cleaving complement factor B from activated C3 (C3bbb)
  • serine protease that is secreted by adipocytes into the bloodstream
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS immunity/defense
    text anti-pathogen response
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    factor D-deficient mice had no apparent abnormality in development and their body weights were similar to those of factor D-sufficient littermates